Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones

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dc.bibliographicCitation.firstPage3687182
dc.bibliographicCitation.journalTitleJournal of chemistryeng
dc.bibliographicCitation.volume2017
dc.contributor.authorVu, Vu Van
dc.contributor.authorNhung, Trinh Thi
dc.contributor.authorThanh, Nguyen Thi
dc.contributor.authorChinh, Luu Van
dc.contributor.authorTien, Vu Dinh
dc.contributor.authorThuy, Vu Thu
dc.contributor.authorThi Thao, Do
dc.contributor.authorNam, Nguyen Hai
dc.contributor.authorKoeckritz, Angela
dc.contributor.authorVu, Tran Khac
dc.date.accessioned2023-03-07T10:42:55Z
dc.date.available2023-03-07T10:42:55Z
dc.date.issued2017
dc.description.abstractA series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11730
dc.identifier.urihttp://dx.doi.org/10.34657/10763
dc.language.isoeng
dc.publisherNew York, NY [u.a.] : Hindawi
dc.relation.doihttps://doi.org/10.1155/2017/3687182
dc.relation.essn2090-9071
dc.relation.issn2090-9063
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc540
dc.subject.othergossypol derivativeseng
dc.subject.otherantiviral activitieseng
dc.subject.othercell-deatheng
dc.subject.otherinhibitorseng
dc.subject.otherbcl-2eng
dc.subject.otheranalogseng
dc.subject.otherdesigneng
dc.subject.otherplantseng
dc.titleSynthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazoneseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorLIKAT
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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