Palladium-Catalyzed Cascade Carbonylation to α,β-Unsaturated Piperidones via Selective Cleavage of Carbon-Carbon Triple Bonds
dc.bibliographicCitation.firstPage | 22393 | eng |
dc.bibliographicCitation.issue | 41 | eng |
dc.bibliographicCitation.lastPage | 22400 | eng |
dc.bibliographicCitation.volume | 60 | eng |
dc.contributor.author | Ge, Yao | |
dc.contributor.author | Ye, Fei | |
dc.contributor.author | Yang, Ji | |
dc.contributor.author | Spannenberg, Anke | |
dc.contributor.author | Jiao, Haijun | |
dc.contributor.author | Jackstell, Ralf | |
dc.contributor.author | Beller, Matthias | |
dc.date.accessioned | 2022-02-10T09:00:28Z | |
dc.date.available | 2022-02-10T09:00:28Z | |
dc.date.issued | 2021 | |
dc.description.abstract | A direct and selective synthesis of α,β-unsaturated piperidones by a new palladium-catalyzed cascade carbonylation is described. In the presented protocol, easily available propargylic alcohols react with aliphatic amines to provide a broad variety of interesting heterocycles. Key to the success of this transformation is a remarkable catalytic cleavage of the present carbon–carbon triple bond by using a specific catalyst with 2-diphenylphosphinopyridine as ligand and appropriate reaction conditions. Mechanistic studies and control experiments revealed branched unsaturated acid 11 as crucial intermediate. © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/8001 | |
dc.identifier.uri | https://doi.org/10.34657/7042 | |
dc.language.iso | eng | eng |
dc.publisher | Weinheim : Wiley-VCH | eng |
dc.relation.doi | https://doi.org/10.1002/anie.202108120 | |
dc.relation.essn | 1521-3773 | |
dc.relation.ispartofseries | Angewandte Chemie - International Edition 60 (2021), Nr. 41 | eng |
dc.rights.license | CC BY-NC 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.subject | bond cleavage | eng |
dc.subject | cascade carbonylation | eng |
dc.subject | homogeneous catalysis | eng |
dc.subject | palladium | eng |
dc.subject | α,β-unsaturated piperidones | eng |
dc.subject.ddc | 540 | eng |
dc.title | Palladium-Catalyzed Cascade Carbonylation to α,β-Unsaturated Piperidones via Selective Cleavage of Carbon-Carbon Triple Bonds | eng |
dc.type | article | eng |
dc.type | Text | eng |
dcterms.bibliographicCitation.journalTitle | Angewandte Chemie - International Edition | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | LIKAT | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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