The synergistic effect of chlorotoxin‑mApoE in boosting drug‑loaded liposomes across the BBB

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dc.bibliographicCitation.firstPage115eng
dc.bibliographicCitation.issue1eng
dc.bibliographicCitation.journalTitleJournal of nanobiotechnologyeng
dc.bibliographicCitation.volume17eng
dc.contributor.authorFormicola, Beatrice
dc.contributor.authorDal Magro, Roberta
dc.contributor.authorMontefusco‑Pereira, Carlos V.
dc.contributor.authorLehr, Claus‑Michael
dc.contributor.authorKoch, Marcus
dc.contributor.authorRusso, Laura
dc.contributor.authorGrasso, Gianvito
dc.contributor.authorDeriu, Marco A.
dc.contributor.authorDanani, Andrea
dc.contributor.authorBourdoulous, Sandrine
dc.contributor.authorRe, Francesca
dc.date.accessioned2021-11-09T07:13:46Z
dc.date.available2021-11-09T07:13:46Z
dc.date.issued2019
dc.description.abstractWe designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s).eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/7212
dc.identifier.urihttps://doi.org/10.34657/6259
dc.language.isoengeng
dc.publisherLondon : Biomed Centraleng
dc.relation.doihttps://doi.org/10.1186/s12951-019-0546-3
dc.relation.essn1477-3155
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc540eng
dc.subject.ddc610eng
dc.subject.otherBlood-brain barriereng
dc.subject.otherBraineng
dc.subject.otherChlorotoxineng
dc.subject.otherDoxorubicineng
dc.subject.otherDrug deliveryeng
dc.subject.otherGlioblastomaeng
dc.subject.otherLiposomeseng
dc.subject.otherNanoparticleseng
dc.titleThe synergistic effect of chlorotoxin‑mApoE in boosting drug‑loaded liposomes across the BBBeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorINMeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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