Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
dc.bibliographicCitation.issue | 3 | eng |
dc.bibliographicCitation.journalTitle | Breast Cancer Research | eng |
dc.bibliographicCitation.volume | 12 | |
dc.contributor.author | Cadenas, Cristina | |
dc.contributor.author | Franckenstein, Dennis | |
dc.contributor.author | Schmidt, Marcus | |
dc.contributor.author | Gehrmann, Mathias | |
dc.contributor.author | Hermes, Matthias | |
dc.contributor.author | Geppert, Bettina | |
dc.contributor.author | Schormann, Wiebke | |
dc.contributor.author | Maccoux, Lindsey J. | |
dc.contributor.author | Schug, Markus | |
dc.contributor.author | Schumann, Anika | |
dc.contributor.author | Wilhelm, Christian | |
dc.contributor.author | Freis, Evgenia | |
dc.contributor.author | Ickstadt, Katja | |
dc.contributor.author | Rahnenführer, Jörg | |
dc.contributor.author | Baumbach, Jörg I. | |
dc.contributor.author | Sickmann, Albert | |
dc.contributor.author | Hengstler, Jan G. | |
dc.date.accessioned | 2018-02-19T09:50:09Z | |
dc.date.available | 2019-06-28T08:33:10Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Introduction: The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. Methods: Analysis of the association of TXNRD1 and TXNIP RNA expression with the metastasis-free interval (MFI) was performed in 788 patients with node-negative breast cancer, consisting of three individual cohorts (Mainz, Rotterdam and Transbig). Correlation with metagenes and conventional clinical parameters (age, pT stage, grading, hormone and ERBB2 status) was explored. MCF-7 cells with a doxycycline-inducible expression of an oncogenic ERBB2 were used to investigate the influence of ERBB2 on TXNRD1 and TXNIP transcription. Results: TXNRD1 was associated with worse MFI in the combined cohort (hazard ratio = 1.955; P < 0.001) as well as in all three individual cohorts. In contrast, TXNIP was associated with better prognosis (hazard ratio = 0.642; P < 0.001) and similar results were obtained in all three subcohorts. Interestingly, patients with ERBB2-status-positive tumors expressed higher levels of TXNRD1. Induction of ERBB2 in MCF-7 cells caused not only an immediate increase in TXNRD1 but also a strong decrease in TXNIP. A subsequent upregulation of TXNIP as cells undergo senescence was accompanied by a strong increase in levels of reactive oxygen species. Conclusions: TXNRD1 and TXNIP are associated with prognosis in breast cancer, and ERBB2 seems to be one of the factors shifting balances of both factors of the redox control system in a prognostic unfavorable manner. | |
dc.description.version | publishedVersion | eng |
dc.format | application/pdf | |
dc.identifier.uri | https://doi.org/10.34657/1758 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/3683 | |
dc.language.iso | eng | eng |
dc.publisher | London : BioMed Central | |
dc.relation.doi | https://doi.org/10.1186/bcr2599 | |
dc.rights.license | CC BY 2.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/2.0/ | eng |
dc.subject.ddc | 610 | |
dc.subject.other | Apoptosis Signal Regulate Kinase | eng |
dc.subject.other | TXNIP Expression | eng |
dc.subject.other | ERBB2 Status | eng |
dc.subject.other | Oncogenic ERBB2 | eng |
dc.subject.other | NeuT Cell | eng |
dc.title | Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer | |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | ISAS | eng |
wgl.contributor | IfADo | eng |
wgl.subject | Medizin, Gesundheit | eng |
wgl.type | Zeitschriftenartikel | eng |
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