Cardio-respiratory coordination increases during sleep apnea

dc.bibliographicCitation.firstPagee93866eng
dc.bibliographicCitation.issue4eng
dc.bibliographicCitation.journalTitlePLoS ONEeng
dc.bibliographicCitation.volume9eng
dc.contributor.authorRiedl, M.
dc.contributor.authorMüller, A.
dc.contributor.authorKraemer, J.F.
dc.contributor.authorPenzel, T.
dc.contributor.authorKurths, J.
dc.contributor.authorWessel, N.
dc.date.accessioned2020-08-01T15:36:07Z
dc.date.available2020-08-01T15:36:07Z
dc.date.issued2014
dc.description.abstractCardiovascular diseases are the main source of morbidity and mortality in the United States with costs of more than $170 billion. Repetitive respiratory disorders during sleep are assumed to be a major cause of these diseases. Therefore, the understanding of the cardio-respiratory regulation during these events is of high public interest. One of the governing mechanisms is the mutual influence of the cardiac and respiratory oscillations on their respective onsets, the cardiorespiratory coordination (CRC). We analyze this mechanism based on nocturnal measurements of 27 males suffering from obstructive sleep apnea syndrome. Here we find, by using an advanced analysis technique, the coordigram, not only that the occurrence of CRC is significantly more frequent during respiratory sleep disturbances than in normal respiration (p-value<10-51) but also more frequent after these events (p-value<10-15). Especially, the latter finding contradicts the common assumption that spontaneous CRC can only be observed in epochs of relaxed conditions, while our newly discovered epochs of CRC after disturbances are characterized by high autonomic stress. Our findings on the connection between CRC and the appearance of sleep-disordered events require a substantial extension of the current understanding of obstructive sleep apneas and hypopneas.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://doi.org/10.34657/3887
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/5258
dc.language.isoengeng
dc.publisherSan Francisco, CA : Public Library of Science (PLoS)eng
dc.relation.doihttps://doi.org/10.1371/journal.pone.0093866
dc.relation.issn1932-6203
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc610eng
dc.subject.otherarticleeng
dc.subject.otherautonomic nervous systemeng
dc.subject.otherbreathing patterneng
dc.subject.othercardiorespiratory coordinationeng
dc.subject.othercardiovascular functioneng
dc.subject.otherclinical articleeng
dc.subject.othercoordinationeng
dc.subject.otherhumaneng
dc.subject.othermaleeng
dc.subject.othermental stresseng
dc.subject.otheroscillationeng
dc.subject.otherREM sleepeng
dc.subject.otherrespiration controleng
dc.subject.othersignal detectioneng
dc.subject.othersleep disordered breathingeng
dc.subject.otheradulteng
dc.subject.otherbiological modeleng
dc.subject.otherbreathing rateeng
dc.subject.otherCardiovascular Diseaseseng
dc.subject.othercomplicationeng
dc.subject.otherheart rateeng
dc.subject.otherpathophysiologyeng
dc.subject.otherphysiologyeng
dc.subject.othersleep disordered breathingeng
dc.subject.othersleep stageeng
dc.subject.otherAdulteng
dc.subject.otherAutonomic Nervous Systemeng
dc.subject.otherCardiovascular Diseaseseng
dc.subject.otherHeart Rateeng
dc.subject.otherHumanseng
dc.subject.otherMaleeng
dc.subject.otherModels, Cardiovasculareng
dc.subject.otherRespiratory Rateeng
dc.subject.otherSleep Apnea Syndromeseng
dc.subject.otherSleep Apnea, Obstructiveeng
dc.subject.otherSleep Stageseng
dc.titleCardio-respiratory coordination increases during sleep apneaeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorPIKeng
wgl.subjectMedizin, Gesundheiteng
wgl.typeZeitschriftenartikeleng
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