Dimensionality of rolled-up nanomembranes controls neural stem cell migration mechanism

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dc.bibliographicCitation.firstPage5530eng
dc.bibliographicCitation.issue8eng
dc.bibliographicCitation.lastPage5538eng
dc.bibliographicCitation.volume15
dc.contributor.authorKoch, Britta
dc.contributor.authorMeyer, Anne K.
dc.contributor.authorHelbig, Linda
dc.contributor.authorHarazim, Stefan M.
dc.contributor.authorStorch, Alexander
dc.contributor.authorSanchez, Samuel
dc.contributor.authorSchmidt, Oliver G.
dc.date.accessioned2018-06-07T04:42:08Z
dc.date.available2019-06-28T07:31:36Z
dc.date.issued2015
dc.description.abstractWe employ glass microtube structures fabricated by rolledup nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.eng
dc.description.versionpublishedVersioneng
dc.formatapplication/pdf
dc.identifier.urihttps://doi.org/10.34657/4955
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/1463
dc.language.isoengeng
dc.publisherWashington D.C. : American Chemical Societyeng
dc.relation.doihttps://doi.org/10.1021/acs.nanolett.5b02099
dc.relation.ispartofseriesNano Letters, Volume 15, Issue 8, Page 5530-5538eng
dc.rights.licenseCC BY 3.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/eng
dc.subjectNanomembraneseng
dc.subjectrolled-up nanotechnologyeng
dc.subject3D cell culture scaffoldeng
dc.subjectspatial confinementeng
dc.subjectneural stem cellseng
dc.subjectcell migrationeng
dc.subject.ddc620eng
dc.titleDimensionality of rolled-up nanomembranes controls neural stem cell migration mechanismeng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleNano Letterseng
tib.accessRightsopenAccesseng
wgl.contributorIFWDeng
wgl.subjectIngenieurwissenschafteneng
wgl.subjectMedizin, Gesundheiteng
wgl.typeZeitschriftenartikeleng
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