The interaction of chondroitin sulfate with a lipid monolayer observed by using nonlinear vibrational spectroscopy
dc.bibliographicCitation.firstPage | 13389 | eng |
dc.bibliographicCitation.issue | 23 | eng |
dc.bibliographicCitation.journalTitle | Physical chemistry, chemical physics : PCCP | eng |
dc.bibliographicCitation.lastPage | 13395 | eng |
dc.bibliographicCitation.volume | 23 | eng |
dc.contributor.author | Szekeres, Gergo Peter | |
dc.contributor.author | Krekic, Szilvia | |
dc.contributor.author | Miller, Rebecca L. | |
dc.contributor.author | Mero, Mark | |
dc.contributor.author | Pagel, Kevin | |
dc.contributor.author | Heiner, Zsuzsanna | |
dc.date.accessioned | 2022-04-05T12:18:36Z | |
dc.date.available | 2022-04-05T12:18:36Z | |
dc.date.issued | 2021 | |
dc.description.abstract | The first vibrational sum-frequency generation (VSFG) spectra of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at air–liquid interface are reported here, collected at a laser repetition rate of 100 kHz. By studying the VSFG spectra in the regions of 1050–1450 cm−1, 2750–3180 cm−1, and 3200–3825 cm−1, it was concluded that in the presence of Ca2+ ions, the head groups together with the head-group-bound water molecules in the DPPC monolayer are strongly influenced by the interaction with CS, while the organization of the phospholipid tails remains mostly unchanged. The interactions were observed at a CS concentration below 200 nM, which exemplifies the potential of VSFG in studying biomolecular interactions at low physiological concentrations. The VSFG spectra recorded in the O–H stretching region at chiral polarization combination imply that CS molecules are organized into ordered macromolecular superstructures with a chiral secondary structure. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/8587 | |
dc.identifier.uri | https://doi.org/10.34657/7625 | |
dc.language.iso | eng | eng |
dc.publisher | Cambridge : RSC Publ. | eng |
dc.relation.doi | https://doi.org/10.1039/d1cp01975a | |
dc.relation.essn | 1463-9084 | |
dc.rights.license | CC BY 3.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | Molecules | eng |
dc.subject.other | Phase interfaces | eng |
dc.subject.other | Phospholipids | eng |
dc.subject.other | Stereochemistry | eng |
dc.subject.other | Sulfur compounds | eng |
dc.subject.other | Air liquid interfaces | eng |
dc.subject.other | Biomolecular interactions | eng |
dc.subject.other | Chondroitin sulfates | eng |
dc.subject.other | Dipalmitoyl phosphatidylcholine | eng |
dc.subject.other | Laser repetition rate | eng |
dc.subject.other | Nonlinear vibrational spectroscopy | eng |
dc.subject.other | hysiological concentrations | eng |
dc.subject.other | Vibrational sum-frequency generations | eng |
dc.subject.other | Monolayers | eng |
dc.subject.other | calcium | eng |
dc.subject.other | chondroitin sulfate | eng |
dc.subject.other | dipalmitoylphosphatidylcholine | eng |
dc.subject.other | water | eng |
dc.subject.other | chemistry | eng |
dc.subject.other | spectroscopy | eng |
dc.subject.other | 1,2-Dipalmitoylphosphatidylcholine | eng |
dc.subject.other | Calcium | eng |
dc.subject.other | Chondroitin Sulfates | eng |
dc.subject.other | Spectrum Analysis | eng |
dc.subject.other | Water | eng |
dc.title | The interaction of chondroitin sulfate with a lipid monolayer observed by using nonlinear vibrational spectroscopy | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | MBI | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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