Cardiac contraction induces discordant alternans and localized block
dc.bibliographicCitation.seriesTitle | WIAS Preprints | eng |
dc.bibliographicCitation.volume | 2045 | |
dc.contributor.author | Radszuweit, Markus | |
dc.contributor.author | Alvarez-Lacalle, Enrique | |
dc.contributor.author | Bär, Markus | |
dc.contributor.author | Echebarria, Blas | |
dc.date.accessioned | 2016-03-24T17:36:51Z | |
dc.date.available | 2019-06-28T08:11:09Z | |
dc.date.issued | 2014 | |
dc.description.abstract | In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e. alternations in the duration of the cardiac action potential, that occur at fast pacing rates and are known to be pro-arrhythmic. We show that small stretch-activated currents can produce large effects and cause a transition from in-phase to off-phase alternations (i.e. from concordant to discordant alternans) and to conduction blocks. We demonstrate numerically and analytically that this effect is the result of a generic change in the slope of the conduction velocity restitution curve due to electromechanical coupling. Thus, excitation-contraction coupling can potentially play a relevant role in the transition to reentry and fibrillation. | eng |
dc.description.version | publishedVersion | eng |
dc.format | application/pdf | |
dc.identifier.issn | 2198-5855 | |
dc.identifier.uri | https://doi.org/10.34657/2085 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/2789 | |
dc.language.iso | eng | eng |
dc.publisher | Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik | eng |
dc.relation.issn | 0946-8633 | eng |
dc.rights.license | This document may be downloaded, read, stored and printed for your own use within the limits of § 53 UrhG but it may not be distributed via the internet or passed on to external parties. | eng |
dc.rights.license | Dieses Dokument darf im Rahmen von § 53 UrhG zum eigenen Gebrauch kostenfrei heruntergeladen, gelesen, gespeichert und ausgedruckt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. | ger |
dc.subject.ddc | 510 | eng |
dc.subject.other | Nonlinear dynamics | eng |
dc.subject.other | cardiac alternans | eng |
dc.subject.other | amplitude equations | eng |
dc.title | Cardiac contraction induces discordant alternans and localized block | eng |
dc.type | Report | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | WIAS | eng |
wgl.subject | Mathematik | eng |
wgl.type | Report / Forschungsbericht / Arbeitspapier | eng |
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