Digitally Fabricated and Naturally Augmented In Vitro Tissues

dc.bibliographicCitation.firstPage2001253eng
dc.bibliographicCitation.issue2eng
dc.bibliographicCitation.volume10eng
dc.contributor.authorDuarte Campos, Daniela F.
dc.contributor.authorDe Laporte, Laura
dc.date.accessioned2021-07-29T13:10:16Z
dc.date.available2021-07-29T13:10:16Z
dc.date.issued2020
dc.description.abstractHuman in vitro tissues are extracorporeal 3D cultures of human cells embedded in biomaterials, commonly hydrogels, which recapitulate the heterogeneous, multiscale, and architectural environment of the human body. Contemporary strategies used in 3D tissue and organ engineering integrate the use of automated digital manufacturing methods, such as 3D printing, bioprinting, and biofabrication. Human tissues and organs, and their intra- and interphysiological interplay, are particularly intricate. For this reason, attentiveness is rising to intersect materials science, medicine, and biology with arts and informatics. This report presents advances in computational modeling of bioink polymerization and its compatibility with bioprinting, the use of digital design and fabrication in the development of fluidic culture devices, and the employment of generative algorithms for modeling the natural and biological augmentation of in vitro tissues. As a future direction, the use of serially linked in vitro tissues as human body-mimicking systems and their application in drug pharmacokinetics and metabolism, disease modeling, and diagnostics are discussed. © 2020 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbHeng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6415
dc.identifier.urihttps://doi.org/10.34657/5462
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCHeng
dc.relation.doihttps://doi.org/10.1002/adhm.202001253
dc.relation.essn2192-2659
dc.relation.ispartofseriesAdvanced healthcare materials 10 (2020), Nr. 2eng
dc.relation.issn2192-2640
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectbioprinting; computational modelingeng
dc.subjectdigital fabricationeng
dc.subjecthydrogelseng
dc.subjectin vitro tissueseng
dc.subject.ddc540eng
dc.subject.ddc610eng
dc.titleDigitally Fabricated and Naturally Augmented In Vitro Tissueseng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleAdvanced healthcare materialseng
tib.accessRightsopenAccesseng
wgl.contributorDWIeng
wgl.subjectIngenieurwissenschafteneng
wgl.typeZeitschriftenartikeleng
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