Proteomic insights into non-small cell lung cancer: New ideas for cancer diagnosis and therapy from a functional viewpoint

dc.bibliographicCitation.firstPage25eng
dc.bibliographicCitation.journalTitleEuPA Open Proteomicseng
dc.bibliographicCitation.lastPage39eng
dc.bibliographicCitation.volume4
dc.contributor.authorLinxweiler, Johannes
dc.contributor.authorKollipara, Laxmikanth
dc.contributor.authorZahedi, René P.
dc.contributor.authorLampel, Pavel
dc.contributor.authorZimmermann, Richard
dc.contributor.authorGreiner, Markus
dc.date.accessioned2016-03-24T17:36:59Z
dc.date.available2019-06-28T08:33:11Z
dc.date.issued2014
dc.description.abstractWe recently characterized SEC62 as an oncogene in non-small-cell lung cancer (NSCLC). Here we aimed to gain further insight into the molecular mechanisms of the cancer-related functions of this oncogene. We performed 2D-DIGE proteome analysis of tumor material from patients with NSCLC and of HEK293 cells stably overexpressing plasmid-encoded SEC62, combined with investigation of the Sec62 interactome. Furthermore, we analyzed the proteomic effects of siRNA-mediated depletion of the Sec62-interacting protein Sec63. We identified a comprehensive list of differentially regulated proteins, providing new insights into the molecular mechanisms of the cancer-related functions of Sec62 in cell migration, drug resistance, and Ca2+-homeostasis.
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://doi.org/10.34657/1737
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/3701
dc.language.isoengeng
dc.publisherAmsterdam : Elsevier
dc.relation.doihttps://doi.org/10.1016/j.euprot.2014.05.004
dc.rights.licenseCC BY-NC-ND 3.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.subject.ddc610
dc.subject.otherNon-small cell lung cancer (NSCLC)eng
dc.subject.otherSec62eng
dc.subject.other2D-DIGEeng
dc.subject.otherVimentineng
dc.subject.otherPlastin 3eng
dc.subject.otherEpithelial-mesenchymal transition (EMT)eng
dc.titleProteomic insights into non-small cell lung cancer: New ideas for cancer diagnosis and therapy from a functional viewpoint
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorISASeng
wgl.subjectMedizin, Gesundheiteng
wgl.typeZeitschriftenartikeleng
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