Proteomic insights into non-small cell lung cancer: New ideas for cancer diagnosis and therapy from a functional viewpoint
dc.bibliographicCitation.firstPage | 25 | eng |
dc.bibliographicCitation.journalTitle | EuPA Open Proteomics | eng |
dc.bibliographicCitation.lastPage | 39 | eng |
dc.bibliographicCitation.volume | 4 | |
dc.contributor.author | Linxweiler, Johannes | |
dc.contributor.author | Kollipara, Laxmikanth | |
dc.contributor.author | Zahedi, René P. | |
dc.contributor.author | Lampel, Pavel | |
dc.contributor.author | Zimmermann, Richard | |
dc.contributor.author | Greiner, Markus | |
dc.date.accessioned | 2016-03-24T17:36:59Z | |
dc.date.available | 2019-06-28T08:33:11Z | |
dc.date.issued | 2014 | |
dc.description.abstract | We recently characterized SEC62 as an oncogene in non-small-cell lung cancer (NSCLC). Here we aimed to gain further insight into the molecular mechanisms of the cancer-related functions of this oncogene. We performed 2D-DIGE proteome analysis of tumor material from patients with NSCLC and of HEK293 cells stably overexpressing plasmid-encoded SEC62, combined with investigation of the Sec62 interactome. Furthermore, we analyzed the proteomic effects of siRNA-mediated depletion of the Sec62-interacting protein Sec63. We identified a comprehensive list of differentially regulated proteins, providing new insights into the molecular mechanisms of the cancer-related functions of Sec62 in cell migration, drug resistance, and Ca2+-homeostasis. | |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://doi.org/10.34657/1737 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/3701 | |
dc.language.iso | eng | eng |
dc.publisher | Amsterdam : Elsevier | |
dc.relation.doi | https://doi.org/10.1016/j.euprot.2014.05.004 | |
dc.rights.license | CC BY-NC-ND 3.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | eng |
dc.subject.ddc | 610 | |
dc.subject.other | Non-small cell lung cancer (NSCLC) | eng |
dc.subject.other | Sec62 | eng |
dc.subject.other | 2D-DIGE | eng |
dc.subject.other | Vimentin | eng |
dc.subject.other | Plastin 3 | eng |
dc.subject.other | Epithelial-mesenchymal transition (EMT) | eng |
dc.title | Proteomic insights into non-small cell lung cancer: New ideas for cancer diagnosis and therapy from a functional viewpoint | |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | ISAS | eng |
wgl.subject | Medizin, Gesundheit | eng |
wgl.type | Zeitschriftenartikel | eng |
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