Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen
dc.bibliographicCitation.firstPage | 136 | |
dc.bibliographicCitation.issue | 1 | |
dc.bibliographicCitation.volume | 11 | |
dc.contributor.author | Miebach, Lea | |
dc.contributor.author | Freund, Eric | |
dc.contributor.author | Horn, Stefan | |
dc.contributor.author | Niessner, Felix | |
dc.contributor.author | Sagwal, Sanjeev Kumar | |
dc.contributor.author | von Woedtke, Thomas | |
dc.contributor.author | Emmert, Steffen | |
dc.contributor.author | Weltmann, Klaus-Dieter | |
dc.contributor.author | Clemen, Ramona | |
dc.contributor.author | Schmidt, Anke | |
dc.contributor.author | Gerling, Torsten | |
dc.contributor.author | Bekeschus, Sander | |
dc.date.accessioned | 2023-04-17T06:37:46Z | |
dc.date.available | 2023-04-17T06:37:46Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Recent research indicated the potential of cold physical plasma in cancer therapy. The plethora of plasma-derived reactive oxygen and nitrogen species (ROS/RNS) mediate diverse antitumor effects after eliciting oxidative stress in cancer cells. We aimed at exploiting this principle using a newly designed dual-jet neon plasma source (Vjet) to treat colorectal cancer cells. A treatment time-dependent ROS/RNS generation induced oxidation, growth retardation, and cell death within 3D tumor spheroids were found. In TUM-CAM, a semi in vivo model, the Vjet markedly reduced vascularized tumors' growth, but an increase of tumor cell immunogenicity or uptake by dendritic cells was not observed. By comparison, the argon-driven single jet kINPen, known to mediate anticancer effects in vitro, in vivo, and in patients, generated less ROS/RNS and terminal cell death in spheroids. In the TUM-CAM model, however, the kINPen was equivalently effective and induced a stronger expression of immunogenic cancer cell death (ICD) markers, leading to increased phagocytosis of kINPen but not Vjet plasma-treated tumor cells by dendritic cells. Moreover, the Vjet was characterized according to the requirements of the DIN-SPEC 91315. Our results highlight the plasma device-specific action on cancer cells for evaluating optimal discharges for plasma cancer treatment. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/11968 | |
dc.identifier.uri | http://dx.doi.org/10.34657/11001 | |
dc.language.iso | eng | |
dc.publisher | London : Nature Publishing Group | |
dc.relation.doi | https://doi.org/10.1038/s41598-020-80512-w | |
dc.relation.essn | 2045-2322 | |
dc.relation.ispartofseries | Scientific Reports 11 (2021), Nr. 1 | eng |
dc.rights.license | CC BY 4.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Animals | eng |
dc.subject | Cell Line, Tumor | eng |
dc.subject | Colorectal Neoplasms | eng |
dc.subject | Humans | eng |
dc.subject | Immunogenic Cell Death | eng |
dc.subject | Mice | eng |
dc.subject | Neon | eng |
dc.subject | Oxidative Stress | eng |
dc.subject | Phagocytosis | eng |
dc.subject | Plasma Gases | eng |
dc.subject | Reactive Nitrogen Species | eng |
dc.subject | Reactive Oxygen Species | eng |
dc.subject | Spheroids, Cellular | eng |
dc.subject.ddc | 500 | |
dc.subject.ddc | 600 | |
dc.title | Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen | eng |
dc.type | article | |
dc.type | Text | |
dcterms.bibliographicCitation.journalTitle | Scientific Reports | |
tib.accessRights | openAccess | |
wgl.contributor | INP | |
wgl.subject | Medizin, Gesundheit | ger |
wgl.type | Zeitschriftenartikel | ger |
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