Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release

dc.bibliographicCitation.firstPage15029eng
dc.bibliographicCitation.issue35eng
dc.bibliographicCitation.journalTitleAngewandte Chemie - International Editioneng
dc.bibliographicCitation.volume59eng
dc.contributor.authorXu, H.
dc.contributor.authorMedina-Sánchez, M.
dc.contributor.authorSchmidt, O.G.
dc.date.accessioned2020-07-17T12:25:26Z
dc.date.available2020-07-17T12:25:26Z
dc.date.issued2020
dc.description.abstractAn integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.eng
dc.description.fondsLeibniz_Fonds
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://doi.org/10.34657/3555
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/4926
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCH Verlageng
dc.relation.doihttps://doi.org/10.1002/anie.202005657
dc.relation.issn1433-7851
dc.rights.licenseCC BY-NC 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/eng
dc.subject.ddc540eng
dc.subject.otherenzymatic releaseeng
dc.subject.othermature sperm selectioneng
dc.subject.othermicroflake synthesiseng
dc.subject.othermicromotoreng
dc.subject.othersperm swarm transporteng
dc.subject.otherControlled drug deliveryeng
dc.subject.otherHyaluronic acideng
dc.subject.otherMicromotorseng
dc.subject.otherBinding mechanismseng
dc.subject.otherCargo deliveryeng
dc.subject.otherIntegrated systemseng
dc.subject.otherMagnetic micromotorseng
dc.subject.otherMicrocarrierseng
dc.subject.otherReproductive systemseng
dc.subject.otherRotating magnetic fieldseng
dc.subject.otherTarget locationeng
dc.subject.otherTargeted drug deliveryeng
dc.titleMagnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Releaseeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIFWDeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Xu et al 2020, Magnetic Micromotors for Multiple Motile Sperm Cells Capture.pdf
Size:
4.44 MB
Format:
Adobe Portable Document Format
Description:
Collections