Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies
dc.bibliographicCitation.firstPage | 4197 | eng |
dc.bibliographicCitation.issue | 8 | eng |
dc.bibliographicCitation.journalTitle | Nano Letters | eng |
dc.bibliographicCitation.volume | 14 | eng |
dc.contributor.author | Xi, W. | |
dc.contributor.author | Schmidt, C.K. | |
dc.contributor.author | Sanchez, S. | |
dc.contributor.author | Gracias, D.H. | |
dc.contributor.author | Carazo-Salas, R.E. | |
dc.contributor.author | Jackson, S.P. | |
dc.contributor.author | Schmidt, O.G. | |
dc.date.accessioned | 2020-11-12T07:22:04Z | |
dc.date.available | 2020-11-12T07:22:04Z | |
dc.date.issued | 2014 | |
dc.description.abstract | We use micropatterning and strain engineering to encapsulate single living mammalian cells into transparent tubular architectures consisting of three-dimensional (3D) rolled-up nanomembranes. By using optical microscopy, we demonstrate that these structures are suitable for the scrutiny of cellular dynamics within confined 3D-microenvironments. We show that spatial confinement of mitotic mammalian cells inside tubular architectures can perturb metaphase plate formation, delay mitotic progression, and cause chromosomal instability in both a transformed and nontransformed human cell line. These findings could provide important clues into how spatial constraints dictate cellular behavior and function. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://doi.org/10.34657/4523 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/5894 | |
dc.language.iso | eng | eng |
dc.publisher | Washington, DC : American Chemical Society | eng |
dc.relation.doi | https://doi.org/10.1021/nl4042565 | |
dc.relation.issn | 1530-6984 | |
dc.rights.license | ACS AuthorChoice | eng |
dc.rights.uri | https://pubs.acs.org/page/policy/authorchoice_termsofuse.html | eng |
dc.subject.ddc | 620 | eng |
dc.subject.other | 3D cell culture scaffold | eng |
dc.subject.other | chromosome segregation errors | eng |
dc.subject.other | mitosis | eng |
dc.subject.other | Nanomembranes | eng |
dc.subject.other | rolled-up nanotechnology | eng |
dc.subject.other | spatial confinement | eng |
dc.subject.other | Cell culture | eng |
dc.subject.other | Chromosomes | eng |
dc.subject.other | Nanostructures | eng |
dc.subject.other | 3-D cell culture | eng |
dc.subject.other | Chromosome segregation | eng |
dc.subject.other | mitosis | eng |
dc.subject.other | Nanomembranes | eng |
dc.subject.other | Spatial confinement | eng |
dc.subject.other | Scaffolds (biology) | eng |
dc.subject.other | artificial membrane | eng |
dc.subject.other | nanomaterial | eng |
dc.subject.other | artificial membrane | eng |
dc.subject.other | chemistry | eng |
dc.subject.other | HeLa cell line | eng |
dc.subject.other | human | eng |
dc.subject.other | metaphase | eng |
dc.subject.other | HeLa Cells | eng |
dc.subject.other | Humans | eng |
dc.subject.other | Membranes, Artificial | eng |
dc.subject.other | Metaphase | eng |
dc.subject.other | Nanostructures | eng |
dc.title | Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IFWD | eng |
wgl.subject | Ingenieurwissenschaften | eng |
wgl.type | Zeitschriftenartikel | eng |
Files
Original bundle
1 - 1 of 1