Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles

dc.bibliographicCitation.firstPage22701eng
dc.bibliographicCitation.issue38eng
dc.bibliographicCitation.lastPage22711eng
dc.bibliographicCitation.volume10eng
dc.contributor.authorWehr, Riccardo
dc.contributor.authorGaitzsch, Jens
dc.contributor.authorDaubian, Davy
dc.contributor.authorFodor, Csaba
dc.contributor.authorMeier, Wolfgang
dc.date.accessioned2022-05-10T09:20:56Z
dc.date.available2022-05-10T09:20:56Z
dc.date.issued2020
dc.description.abstractAqueous self-assembly of amphiphilic block copolymers is studied extensively for biomedical applications like drug delivery and nanoreactors. The commonly used hydrophilic block poly(ethylene oxide) (PEO), however, suffers from several drawbacks. As a potent alternative, poly(glycidol) (PG) has gained increasing interest, benefiting from its easy synthesis, high biocompatibility and flexibility as well as enhanced functionality compared to PEO. In this study, we present a quick and well-controlled synthesis of poly(butylene oxide)-block-poly(glycidol) (PBO-b-PG) amphiphilic diblock copolymers together with a straight-forward self-assembly protocol. Depending on the hydrophilic mass fraction of the copolymer, nanoscopic micelles, worms and polymersomes were formed as well as microscopic giant unilamellar vesicles. The particles were analysed regarding their size and shape, using dynamic and static light scattering, TEM and Cryo-TEM imaging as well as confocal laser scanning microscopy. We have discovered a strong dependence of the formed morphology on the self-assembly method and show that only solvent exchange leads to the formation of homogenous phases. Thus, a variety of different structures can be obtained from a highly flexible copolymer, justifying a potential use in biomedical applications. This journal is © The Royal Society of Chemistry.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/8922
dc.identifier.urihttps://doi.org/10.34657/7960
dc.language.isoengeng
dc.publisherCambridge : RSCeng
dc.relation.doihttps://doi.org/10.1039/d0ra04274a
dc.relation.essn2046-2069
dc.relation.ispartofseriesRSC Advances 10 (2020), Nr. 38eng
dc.rights.licenseCC BY 3.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/eng
dc.subjectBiocompatibilityeng
dc.subjectBlock copolymerseng
dc.subjectButeneseng
dc.subjectControlled drug deliveryeng
dc.subjectEthyleneeng
dc.subjectHydrophilicityeng
dc.subjectLight scatteringeng
dc.subjectMedical applicationseng
dc.subjectPolyethylene oxideseng
dc.subjectAmphiphilic block copolymerseng
dc.subjectAmphiphilic diblock copolymerseng
dc.subjectBiomedical applicationseng
dc.subjectConfocal laser scanning microscopyeng
dc.subjectGiant unilamellar vesicleseng
dc.subjectPoly (ethylene oxide) (PEO)eng
dc.subjectSelf-assembly methodeng
dc.subjectStatic Light Scatteringeng
dc.subjectMicelleseng
dc.subject.ddc540eng
dc.titleDeepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicleseng
dc.titleTexteng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleRSC Advanceseng
tib.accessRightsopenAccesseng
wgl.contributorIPFeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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