Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity
dc.bibliographicCitation.firstPage | 19924 | |
dc.bibliographicCitation.issue | 32 | |
dc.bibliographicCitation.journalTitle | RSC Advances | eng |
dc.bibliographicCitation.lastPage | 19933 | |
dc.bibliographicCitation.volume | 7 | |
dc.contributor.author | Giovannini, Giorgia | |
dc.contributor.author | Kunc, Filip | |
dc.contributor.author | Piras, Carmen C. | |
dc.contributor.author | Stranik, Ondrej | |
dc.contributor.author | Edwards, Alison A. | |
dc.contributor.author | Hall, Andrew J. | |
dc.contributor.author | Gubala, Vladimir | |
dc.date.accessioned | 2023-03-06T07:55:39Z | |
dc.date.available | 2023-03-06T07:55:39Z | |
dc.date.issued | 2017 | |
dc.description.abstract | For successful nanomedicine, it is important that the unique, size-dependent physico-chemical properties of the nanomaterial remain predictably constant during both the storage and the manipulation of the material. Here a novel approach to preserve the colloidal stability and degradation of NPs is described. The concept is simple: (a) a solution of monodisperse particles is formulated into a responsive water- or PBS-based hydrogel; (b) the gel can be reversibly turned into a solution after long term storage by shaking it by hand; (c) the NP can be diluted and used in any desired application without the need for excessive manipulation. The differences between the physico-chemical properties of NPs stored in solution and in gel are compared. Two types of NPs were involved in this study: silica NPs of ∼100 nm and Au-NPs of 30 and 80 nm in diameter. The key findings are: the fibrous matrix of the hydrogel limits the NP mobility, significantly reduces NP aggregation and conserves the NP morphology; both the hydrogelator and the NPs show negligible toxicity towards the model U937 human hematopoietic cell line; undesired leaching of cargo material loaded inside the particles is reduced, which could be an important feature for drug delivery systems. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/11690 | |
dc.identifier.uri | http://dx.doi.org/10.34657/10723 | |
dc.language.iso | eng | |
dc.publisher | London : RSC Publishing | |
dc.relation.doi | https://doi.org/10.1039/c7ra02427d | |
dc.relation.essn | 2046-2069 | |
dc.rights.license | CC BY 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject.ddc | 540 | |
dc.subject.other | Colloidal Stability | eng |
dc.subject.other | Drug delivery system | eng |
dc.subject.other | Hematopoietic cell line | eng |
dc.subject.other | Important features | eng |
dc.subject.other | Long-term storage | eng |
dc.subject.other | Mono-disperse particles | eng |
dc.subject.other | Physicochemical property | eng |
dc.subject.other | Silica nanoparticles | eng |
dc.title | Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | |
wgl.contributor | IPHT | |
wgl.subject | Chemie | ger |
wgl.type | Zeitschriftenartikel | ger |
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