Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy
dc.bibliographicCitation.firstPage | 42855 | |
dc.bibliographicCitation.issue | 1 | |
dc.bibliographicCitation.journalTitle | Scientific Reports | eng |
dc.bibliographicCitation.volume | 7 | |
dc.contributor.author | Aliperta, Roberta | |
dc.contributor.author | Welzel, Petra B. | |
dc.contributor.author | Bergmann, Ralf | |
dc.contributor.author | Freudenberg, Uwe | |
dc.contributor.author | Berndt, Nicole | |
dc.contributor.author | Feldmann, Anja | |
dc.contributor.author | Arndt, Claudia | |
dc.contributor.author | Koristka, Stefanie | |
dc.contributor.author | Stanzione, Marcello | |
dc.contributor.author | Cartellieri, Marc | |
dc.contributor.author | Ehninger, Armin | |
dc.contributor.author | Ehninger, Gerhard | |
dc.contributor.author | Werner, Carsten | |
dc.contributor.author | Pietzsch, Jens | |
dc.contributor.author | Steinbach, Jörg | |
dc.contributor.author | Bornhäuser, Martin | |
dc.contributor.author | Bachmann, Michael P. | |
dc.date.accessioned | 2023-04-27T11:59:30Z | |
dc.date.available | 2023-04-27T11:59:30Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Combining stem cells with biomaterial scaffolds provides a promising strategy for the development of drug delivery systems. Here we propose an innovative immunotherapeutic organoid by housing human mesenchymal stromal cells (MSCs), gene-modified for the secretion of an anti-CD33-anti-CD3 bispecific antibody (bsAb), in a small biocompatible star-shaped poly(ethylene glycol)-heparin cryogel scaffold as a transplantable and low invasive therapeutic machinery for the treatment of acute myeloid leukemia (AML). The macroporous biohybrid cryogel platform displays effectiveness in supporting proliferation and survival of bsAb-releasing-MSCs overtime in vitro and in vivo, avoiding cell loss and ensuring a constant release of sustained and detectable levels of bsAb capable of triggering T-cell-mediated anti-tumor responses and a rapid regression of CD33 + AML blasts. This therapeutic device results as a promising and safe alternative to the continuous administration of short-lived immunoagents and paves the way for effective bsAb-based therapeutic strategies for future tumor treatments. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/12129 | |
dc.identifier.uri | http://dx.doi.org/10.34657/11163 | |
dc.language.iso | eng | |
dc.publisher | London : Nature Publishing Group | |
dc.relation.doi | https://doi.org/10.1038/srep42855 | |
dc.relation.essn | 2045-2322 | |
dc.rights.license | CC BY 4.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject.ddc | 500 | |
dc.subject.ddc | 600 | |
dc.subject.other | Animals | eng |
dc.subject.other | Antibodies, Bispecific | eng |
dc.subject.other | Biocompatible Materials | eng |
dc.subject.other | Cell Line, Tumor | eng |
dc.subject.other | Cryogels | eng |
dc.subject.other | Humans | eng |
dc.subject.other | Immunotherapy | eng |
dc.subject.other | Mesenchymal Stromal Cells | eng |
dc.subject.other | Mice | eng |
dc.subject.other | Neoplasms | eng |
dc.subject.other | Tissue Scaffolds | eng |
dc.subject.other | Xenograft Model Antitumor Assays | eng |
dc.title | Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | |
wgl.contributor | IPF | |
wgl.subject | Medizin, Gesundheit | ger |
wgl.type | Zeitschriftenartikel | ger |
Files
Original bundle
1 - 1 of 1