Plasma medical oncology: Immunological interpretation of head and neck squamous cell carcinoma
dc.bibliographicCitation.firstPage | 1900258 | eng |
dc.bibliographicCitation.issue | 10 | eng |
dc.bibliographicCitation.journalTitle | Plasma processes and polymers | eng |
dc.bibliographicCitation.volume | 17 | eng |
dc.contributor.author | Witzke, Katharina | |
dc.contributor.author | Seebauer, Christian | |
dc.contributor.author | Jesse, Katja | |
dc.contributor.author | Kwiatek, Elisa | |
dc.contributor.author | Berner, Julia | |
dc.contributor.author | Semmler, Marie‐Luise | |
dc.contributor.author | Boeckmann, Lars | |
dc.contributor.author | Emmert, Steffen | |
dc.contributor.author | Weltmann, Klaus‐Dieter | |
dc.contributor.author | Metelmann, Hans‐Robert | |
dc.contributor.author | Bekeschus, Sander | |
dc.date.accessioned | 2021-12-10T06:18:13Z | |
dc.date.available | 2021-12-10T06:18:13Z | |
dc.date.issued | 2020 | |
dc.description.abstract | The prognosis of patients suffering from advanced-stage head and neck squamous cell carcinoma (HNSCC) remains poor. Medical gas plasma therapy receives growing attention as a novel anticancer modality. Our recent prospective observational study on HNSCC patients suffering from contaminated tumor ulcerations without lasting remission after first-line anticancer therapy showed remarkable efficacy of gas plasma treatment, with the ulcerated tumor surface decreasing by up to 80%. However, tumor growth relapsed, and this biphasic response may be a consequence of immunological and molecular changes in the tumor microenvironment that could be caused by (a) immunosuppression, (b) tumor cell adaption, (c) loss of microbe-induced immunostimulation, and/or (d) stromal cell adaption. These considerations may be vital for the design of clinical plasma trials in the future. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/7666 | |
dc.identifier.uri | https://doi.org/10.34657/6713 | |
dc.language.iso | eng | eng |
dc.publisher | Hoboken, NJ : Wiley Interscience | eng |
dc.relation.doi | https://doi.org/10.1002/ppap.201900258 | |
dc.relation.essn | 1612-8869 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 530 | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | cold physical plasma | eng |
dc.subject.other | HNSCC | eng |
dc.subject.other | kINPen | eng |
dc.subject.other | plasma medicine | eng |
dc.subject.other | tumor microenvironment | eng |
dc.title | Plasma medical oncology: Immunological interpretation of head and neck squamous cell carcinoma | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | INP | eng |
wgl.subject | Physik | eng |
wgl.type | Zeitschriftenartikel | eng |
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