Free boundary limits of coupled bulk-surface models for receptor-ligand interactions on evolving domains

Abstract

We derive various novel free boundary problems as limits of a coupled bulk-surface reaction-diffusion system modelling ligand-receptor dynamics on evolving domains. These limiting free boundary problems may be formulated as Stefan-type problems on an evolving hypersurface. Our results are new even in the setting where there is no domain evolution. The models are of particular relevance to a number of applications in cell biology. The analysis utilises L∞-estimates in the manner of De Giorgi iterations and other technical tools, all in an evolving setting. We also report on numerical simulations.