Compartmentalized Jet Polymerization as a High-Resolution Process to Continuously Produce Anisometric Microgel Rods with Adjustable Size and Stiffness

dc.bibliographicCitation.firstPage1903668eng
dc.bibliographicCitation.issue49eng
dc.bibliographicCitation.volume31eng
dc.contributor.authorKrüger, Andreas J.D.
dc.contributor.authorBakirman, Onur
dc.contributor.authorGuerzoni, Luis P.B.
dc.contributor.authorJans, Alexander
dc.contributor.authorGehlen, David B.
dc.contributor.authorRommel, Dirk
dc.contributor.authorHaraszti, Tamás
dc.contributor.authorKuehne, Alexander J.C.
dc.contributor.authorDe Laporte, Laura
dc.date.accessioned2021-12-03T09:17:10Z
dc.date.available2021-12-03T09:17:10Z
dc.date.issued2019
dc.description.abstractIn the past decade, anisometric rod-shaped microgels have attracted growing interest in the materials-design and tissue-engineering communities. Rod-shaped microgels exhibit outstanding potential as versatile building blocks for 3D hydrogels, where they introduce macroscopic anisometry, porosity, or functionality for structural guidance in biomaterials. Various fabrication methods have been established to produce such shape-controlled elements. However, continuous high-throughput production of rod-shaped microgels with simultaneous control over stiffness, size, and aspect ratio still presents a major challenge. A novel microfluidic setup is presented for the continuous production of rod-shaped microgels from microfluidic plug flow and jets. This system overcomes the current limitations of established production methods for rod-shaped microgels. Here, an on-chip gelation setup enables fabrication of soft microgel rods with high aspect ratios, tunable stiffness, and diameters significantly smaller than the channel diameter. This is realized by exposing jets of a microgel precursor to a high intensity light source, operated at specific pulse sequences and frequencies to induce ultra-fast photopolymerization, while a change in flow rates or pulse duration enables variation of the aspect ratio. The microgels can assemble into 3D structures and function as support for cell culture and tissue engineering. © 2019 DWI – Leibniz Institute for Interactive Materials. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimeng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/7621
dc.identifier.urihttps://doi.org/10.34657/6668
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCHeng
dc.relation.doihttps://doi.org/10.1002/adma.201903668
dc.relation.essn1521-4095
dc.relation.ispartofseriesAdvanced Materials 31 (2019), Nr. 49eng
dc.rights.licenseCC BY-NC-ND 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.subjectanisometric microgelseng
dc.subjectjet gelationeng
dc.subjectmicrofluidicseng
dc.subjecton-chip gelationeng
dc.subjectsoft microgelseng
dc.subject.ddc540eng
dc.subject.ddc660eng
dc.titleCompartmentalized Jet Polymerization as a High-Resolution Process to Continuously Produce Anisometric Microgel Rods with Adjustable Size and Stiffnesseng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleAdvanced Materialseng
tib.accessRightsopenAccesseng
wgl.contributorDWIeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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