Practical Catalytic Cleavage of C(sp3)−C(sp3) Bonds in Amines
dc.bibliographicCitation.firstPage | 10693 | eng |
dc.bibliographicCitation.issue | 31 | eng |
dc.bibliographicCitation.journalTitle | Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker : International edition | eng |
dc.bibliographicCitation.lastPage | 10697 | eng |
dc.bibliographicCitation.volume | 58 | eng |
dc.contributor.author | Li, Wu | |
dc.contributor.author | Liu, Weiping | |
dc.contributor.author | Leonard, David K. | |
dc.contributor.author | Rabeah, Jabor | |
dc.contributor.author | Junge, Kathrin | |
dc.contributor.author | Brgckner, Angelika | |
dc.contributor.author | Beller, Matthias | |
dc.date.accessioned | 2021-09-02T11:39:44Z | |
dc.date.available | 2021-09-02T11:39:44Z | |
dc.date.issued | 2019 | |
dc.description.abstract | The selective cleavage of thermodynamically stable C(sp3)−C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα−Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/6671 | |
dc.identifier.uri | https://doi.org/10.34657/5718 | |
dc.language.iso | eng | eng |
dc.publisher | Weinheim : Wiley-VCH | eng |
dc.relation.doi | https://doi.org/10.1002/anie.201903019 | |
dc.relation.essn | 1521-3773 | |
dc.relation.issn | 0570-0833 | |
dc.relation.issn | 1433-7851 | |
dc.rights.license | CC BY-NC-ND 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | air | eng |
dc.subject.other | amines | eng |
dc.subject.other | copper | eng |
dc.subject.other | C−C cleavage | eng |
dc.subject.other | morpholines | eng |
dc.title | Practical Catalytic Cleavage of C(sp3)−C(sp3) Bonds in Amines | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | LIKAT | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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