Practical Catalytic Cleavage of C(sp3)−C(sp3) Bonds in Amines

dc.bibliographicCitation.firstPage10693eng
dc.bibliographicCitation.issue31eng
dc.bibliographicCitation.journalTitleAngewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker : International editioneng
dc.bibliographicCitation.lastPage10697eng
dc.bibliographicCitation.volume58eng
dc.contributor.authorLi, Wu
dc.contributor.authorLiu, Weiping
dc.contributor.authorLeonard, David K.
dc.contributor.authorRabeah, Jabor
dc.contributor.authorJunge, Kathrin
dc.contributor.authorBrgckner, Angelika
dc.contributor.authorBeller, Matthias
dc.date.accessioned2021-09-02T11:39:44Z
dc.date.available2021-09-02T11:39:44Z
dc.date.issued2019
dc.description.abstractThe selective cleavage of thermodynamically stable C(sp3)−C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα−Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6671
dc.identifier.urihttps://doi.org/10.34657/5718
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCHeng
dc.relation.doihttps://doi.org/10.1002/anie.201903019
dc.relation.essn1521-3773
dc.relation.issn0570-0833
dc.relation.issn1433-7851
dc.rights.licenseCC BY-NC-ND 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.subject.ddc540eng
dc.subject.otheraireng
dc.subject.otheramineseng
dc.subject.othercoppereng
dc.subject.otherC−C cleavageeng
dc.subject.othermorpholineseng
dc.titlePractical Catalytic Cleavage of C(sp3)−C(sp3) Bonds in Amineseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorLIKATeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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