In vitro studies of polyhedral oligo silsesquioxanes: Evidence for their low cytotoxicity

dc.bibliographicCitation.firstPage6062
dc.bibliographicCitation.issue9
dc.bibliographicCitation.journalTitleMaterialseng
dc.bibliographicCitation.lastPage6070
dc.bibliographicCitation.volume8
dc.contributor.authorJanaszewska, Anna
dc.contributor.authorGradzinska, Kinga
dc.contributor.authorMarcinkowska, Monika
dc.contributor.authorKlajnert-Maculewicz, Barbara
dc.contributor.authorStanczyk, Wlodzimierz A.
dc.date.accessioned2022-07-29T07:11:02Z
dc.date.available2022-07-29T07:11:02Z
dc.date.issued2015
dc.description.abstractAs scientific literature considers polyhedral oligosilsesquioxanes (POSS) as potential drug delivery systems, it is necessary to check their impact on mammalian cells. Toxicity of octaammonium chloride salt of octaaminopropyl polyhedral oligomeric silsesquioxane (oap-POSS) towards two cell lines: mouse neuroblastoma (N2a) and embryonic mouse hippocampal cells (mHippoE-18) was studied. Experiments consisted of analysis of a cell cycle, cell viability, amount of apoptotic and necrotic cells, and generation of reactive oxygen species (ROS). POSS caused a shift in the cell population from the S and M/G2 phases to the G0/G1 phase. However, the changes affected less than 10% of the cell population and were not accompanied by increased cytotoxicity. POSS did not induce either apoptosis or necrosis and did not generate reactive oxygen species. A cytotoxicity profile of POSS makes it a promising starting material as drug carrier.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/9818
dc.identifier.urihttp://dx.doi.org/10.34657/8856
dc.language.isoengeng
dc.publisherBasel : MDPI
dc.relation.doihttps://doi.org/10.3390/ma8095291
dc.relation.essn1996-1944
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc600
dc.subject.otherApoptosiseng
dc.subject.otherCell cycleeng
dc.subject.otherIn vitro toxicityeng
dc.subject.otherMTT assayeng
dc.subject.otherNecrosiseng
dc.subject.otherPOSSeng
dc.subject.otherReactive oxygen specieseng
dc.subject.otherSilsesquioxaneeng
dc.titleIn vitro studies of polyhedral oligo silsesquioxanes: Evidence for their low cytotoxicityeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIPFger
wgl.subjectChemieger
wgl.subjectBiowissenschaften/Biologieger
wgl.typeZeitschriftenartikelger
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
In_vitro_studies_of.pdf
Size:
589 KB
Format:
Adobe Portable Document Format
Description: