A General and Highly Selective Palladium-Catalyzed Hydroamidation of 1,3-Diynes

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dc.bibliographicCitation.firstPage371eng
dc.bibliographicCitation.issue1eng
dc.bibliographicCitation.journalTitleAngewandte Chemie - International Editioneng
dc.bibliographicCitation.lastPage379eng
dc.bibliographicCitation.volume60eng
dc.contributor.authorLiu, Jiawang
dc.contributor.authorSchneider, Carolin
dc.contributor.authorYang, Ji
dc.contributor.authorWei, Zhihong
dc.contributor.authorJiao, Haijun
dc.contributor.authorFranke, Robert
dc.contributor.authorJackstell, Ralf
dc.contributor.authorBeller, Matthias
dc.date.accessioned2022-01-31T07:31:58Z
dc.date.available2022-01-31T07:31:58Z
dc.date.issued2021
dc.description.abstractA chemo-, regio-, and stereoselective mono-hydroamidation of (un)symmetrical 1,3-diynes is described. Key for the success of this novel transformation is the utilization of an advanced palladium catalyst system with the specific ligand Neolephos. The synthetic value of this general approach to synthetically useful α-alkynyl-α, β-unsaturated amides is showcased by diversification of several structurally complex molecules and marketed drugs. Control experiments and density-functional theory (M06L-SMD) computations also suggest the crucial role of the substrate in controlling the regioselectivity of unsymmetrical 1,3-diynes. © 2020 The Authors. Published by Wiley-VCH GmbHeng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/7948
dc.identifier.urihttps://doi.org/10.34657/6989
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCHeng
dc.relation.doihttps://doi.org/10.1002/anie.202010768
dc.relation.essn1521-3773
dc.rights.licenseCC BY-NC 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/eng
dc.subject.ddc540eng
dc.subject.otherP ligandseng
dc.subject.otheramideseng
dc.subject.otherhydroamidationeng
dc.subject.otherpalladiumeng
dc.subject.otherregioselectivityeng
dc.titleA General and Highly Selective Palladium-Catalyzed Hydroamidation of 1,3-Diyneseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorLIKATeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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