Time-resolved velocity mapping at high magnetic fields: A preclinical comparison between stack‐of‐stars and cartesian 4D-Flow
dc.bibliographicCitation.firstPage | 963807 | eng |
dc.bibliographicCitation.volume | 10 | eng |
dc.contributor.author | Nahardani, Ali | |
dc.contributor.author | Krämer, Martin | |
dc.contributor.author | Ebrahimi, Mahyasadat | |
dc.contributor.author | Herrmann, Karl-Heinz | |
dc.contributor.author | Leistikow, Simon | |
dc.contributor.author | Linsen, Lars | |
dc.contributor.author | Moradi, Sara | |
dc.contributor.author | Reichenbach, Jürgen R. | |
dc.contributor.author | Hoerr, Verena | |
dc.date.accessioned | 2022-11-23T13:06:06Z | |
dc.date.available | 2022-11-23T13:06:06Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Purpose: Prospectively-gated Cartesian 4D-flow (referred to as Cartesian-4D-flow) imaging suffers from long TE and intensified flow-related intravoxel-dephasing especially in preclinical ultra-high field MRI. The ultra-short-echo (UTE) 4D-flow technique can resolve the signal loss in higher-order blood flows; however, the long scan time of the high resolution UTE-4D-flow is considered as a disadvantage for preclinical imaging. To compensate for prolonged acquisitions, an accelerated k0-navigated golden-angle center-out stack-of-stars 4D-flow sequence (referred to as SoS-4D-flow) was implemented at 9.4T and the results were compared to conventional Cartesian-4D-flow mapping in-vitro and in-vivo. Methods: The study was conducted in three steps (A) In-vitro evaluation in a static phantom: to quantify the background velocity bias. (B) In-vitro evaluation in a flowing water phantom: to investigate the effects of polar undersampling (US) on the measured velocities and to compare the spatial velocity profiles between both sequences. (C) In-vivo evaluations: 24 C57BL/6 mice were measured by SoS-4D-flow (n = 14) and Cartesian-4D-flow (n = 10). The peak systolic velocity in the ascending aorta and the background velocity in the anterior chest wall were analyzed for both techniques and were compared to each other. Results: According to the in-vitro analysis, the background velocity bias was significantly lower in SoS-4D-flow than in Cartesian-4D-flow (p < 0.05). Polar US in SoS-4D-flow influenced neither the measured velocity values nor the spatial velocity profiles in comparison to Cartesian-4D-flow. The in-vivo analysis showed significantly higher diastolic velocities in Cartesian-4D-flow than in SoS-4D-flow (p < 0.05). A systemic background bias was observed in the Cartesian velocity maps which influenced their streamline directions and magnitudes. Conclusion: The results of our study showed that at 9.4T SoS-4D-flow provided higher accuracy in slow flow imaging than Cartesian-4D-flow, while the same measurement time could be achieved. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/10424 | |
dc.identifier.uri | http://dx.doi.org/10.34657/9460 | |
dc.language.iso | eng | eng |
dc.publisher | Lausanne : Frontiers Media | eng |
dc.relation.doi | https://doi.org/10.3389/fphy.2022.963807 | |
dc.relation.essn | 2296-424X | |
dc.relation.ispartofseries | Frontiers in physics 10 (2022) | eng |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | 4D-flow | eng |
dc.subject | MRI | eng |
dc.subject | phase-contrast | eng |
dc.subject | stack-of-stars | eng |
dc.subject | UTE | eng |
dc.subject.ddc | 530 | eng |
dc.title | Time-resolved velocity mapping at high magnetic fields: A preclinical comparison between stack‐of‐stars and cartesian 4D-Flow | eng |
dc.type | article | eng |
dc.type | Text | eng |
dcterms.bibliographicCitation.journalTitle | Frontiers in physics | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IPHT | eng |
wgl.subject | Physik | eng |
wgl.type | Zeitschriftenartikel | eng |
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