Cargo shuttling by electrochemical switching of core–shell microgels obtained by a facile one-shot polymerization

dc.bibliographicCitation.firstPage1844eng
dc.bibliographicCitation.issue6eng
dc.bibliographicCitation.lastPage1856eng
dc.bibliographicCitation.volume10eng
dc.contributor.authorMergel, Olga
dc.contributor.authorSchneider, Sabine
dc.contributor.authorTiwari, Rahul
dc.contributor.authorKühn, Philipp T.
dc.contributor.authorKeskin, Damla
dc.contributor.authorStuart, Marc C. A.
dc.contributor.authorSchöttner, Sebastian
dc.contributor.authorde Kanter, Martinus
dc.contributor.authorNoyong, Michael
dc.contributor.authorCaumanns, Tobias
dc.contributor.authorMayer, Joachim
dc.contributor.authorJanzen, Christoph
dc.contributor.authorSimon, Ulrich
dc.contributor.authorGallei, Markus
dc.contributor.authorWöll, Dominik
dc.contributor.authorvan Rijn, Patrick
dc.contributor.authorPlamper, Felix A.
dc.date.accessioned2022-03-29T12:56:19Z
dc.date.available2022-03-29T12:56:19Z
dc.date.issued2019
dc.description.abstractControlling and understanding the electrochemical properties of electroactive polymeric colloids is a highly topical but still a rather unexplored field of research. This is especially true when considering more complex particle architectures like stimuli-responsive microgels, which would entail different kinetic constraints for charge transport within one particle. We synthesize and electrochemically address dual stimuli responsive core-shell microgels, where the temperature-responsiveness modulates not only the internal structure, but also the microgel electroactivity both on an internal and on a global scale. In detail, a facile one-step precipitation polymerization results in architecturally advanced poly(N-isopropylacrylamide-co-vinylferrocene) P(NIPAM-co-VFc) microgels with a ferrocene (Fc)-enriched (collapsed/hard) core and a NIPAM-rich shell. While the remaining Fc units in the shell are electrochemically accessible, the electrochemical activity of Fc in the core is limited due to the restricted mobility of redox active sites and therefore restricted electron transfer in the compact core domain. Still, prolonged electrochemical action and/or chemical oxidation enable a reversible adjustment of the internal microgel structure from core-shell microgels with a dense core to completely oxidized microgels with a highly swollen core and a denser corona. The combination of thermo-sensitive and redox-responsive units being part of the network allows for efficient amplification of the redox response on the overall microgel dimension, which is mainly governed by the shell. Further, it allows for an electrochemical switching of polarity (hydrophilicity/hydrophobicity) of the microgel, enabling an electrochemically triggered uptake and release of active guest molecules. Hence, bactericidal drugs can be released to effectively kill bacteria. In addition, good biocompatibility of the microgels in cell tests suggests suitability of the new microgel system for future biomedical applications. © 2019 The Royal Society of Chemistry.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/8449
dc.identifier.urihttps://doi.org/10.34657/7487
dc.language.isoengeng
dc.publisherCambridge : RSCeng
dc.relation.doihttps://doi.org/10.1039/c8sc04369h
dc.relation.essn2041-6539
dc.relation.ispartofseriesChemical Science 10 (2019), Nr. 6eng
dc.relation.issn2041-6520
dc.rights.licenseCC BY-NC 3.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/eng
dc.subjectAcrylic monomerseng
dc.subjectGelseng
dc.subjectAmideseng
dc.subjectStimuli-responsive microgelseng
dc.subjectRestricted mobilitieseng
dc.subjectPrecipitation polymerizationseng
dc.subjectBiocompatibilityeng
dc.subjectControlled drug deliveryeng
dc.subjectIron compoundseng
dc.subjectOrganometallicseng
dc.subjectPolymerizationeng
dc.subjectRedox reactionseng
dc.subjectTargeted drug deliveryeng
dc.subjectBiomedical applicationseng
dc.subjectCore-shell microgelseng
dc.subjectElectrochemical activitieseng
dc.subjectElectrochemical switchingeng
dc.subjectN- isopropylacrylamideeng
dc.subject.ddc540eng
dc.titleCargo shuttling by electrochemical switching of core–shell microgels obtained by a facile one-shot polymerizationeng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleChemical Scienceeng
tib.accessRightsopenAccesseng
wgl.contributorDWIeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
c8sc04369h.pdf
Size:
1.32 MB
Format:
Adobe Portable Document Format
Description:
Collections