Structural Breakdown of Collagen Type I Elastin Blend Polymerization

dc.bibliographicCitation.firstPage4434
dc.bibliographicCitation.issue20
dc.bibliographicCitation.journalTitlePolymerseng
dc.bibliographicCitation.volume14
dc.contributor.authorWilharm, Nils
dc.contributor.authorFischer, Tony
dc.contributor.authorHayn, Alexander
dc.contributor.authorMayr, Stefan G.
dc.date.accessioned2023-02-10T09:22:54Z
dc.date.available2023-02-10T09:22:54Z
dc.date.issued2022
dc.description.abstractBiopolymer blends are advantageous materials with novel properties that may show performances way beyond their individual constituents. Collagen elastin hybrid gels are a new representative of such materials as they employ elastin’s thermo switching behavior in the physiological temperature regime. Although recent studies highlight the potential applications of such systems, little is known about the interaction of collagen and elastin fibers during polymerization. In fact, the final network structure is predetermined in the early and mostly arbitrary association of the fibers. We investigated type I collagen polymerized with bovine neck ligament elastin with up to 33.3 weight percent elastin and showed, by using a plate reader, zeta potential and laser scanning microscopy (LSM) experiments, that elastin fibers bind in a lateral manner to collagen fibers. Our plate reader experiments revealed an elastin concentration-dependent increase in the polymerization rate, although the rate increase was greatest at intermediate elastin concentrations. As elastin does not significantly change the structural metrics pore size, fiber thickness or 2D anisotropy of the final gel, we are confident to conclude that elastin is incorporated homogeneously into the collagen fibers.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11391
dc.identifier.urihttp://dx.doi.org/10.34657/10425
dc.language.isoeng
dc.publisherBasel : MDPI
dc.relation.doihttps://doi.org/10.3390/polym14204434
dc.relation.essn2073-4360
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc540
dc.subject.othercollageneng
dc.subject.otherelastineng
dc.subject.otherfiber formationeng
dc.subject.otherpolymerizationeng
dc.titleStructural Breakdown of Collagen Type I Elastin Blend Polymerizationeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorIOM
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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