Emerging Biofabrication Techniques : A Review on Natural Polymers for Biomedical Applications

dc.bibliographicCitation.firstPage1209eng
dc.bibliographicCitation.issue8eng
dc.bibliographicCitation.journalTitlePolymerseng
dc.bibliographicCitation.volume13eng
dc.contributor.authorPuertas-Bartolomé, María
dc.contributor.authorMora-Boza, Ana
dc.contributor.authorGarcía-Fernández, Luis
dc.date.accessioned2021-07-02T10:48:48Z
dc.date.available2021-07-02T10:48:48Z
dc.date.issued2021
dc.description.abstractNatural polymers have been widely used for biomedical applications in recent decades. They offer the advantages of resembling the extracellular matrix of native tissues and retaining biochemical cues and properties necessary to enhance their biocompatibility, so they usually improve the cellular attachment and behavior and avoid immunological reactions. Moreover, they offer a rapid degradability through natural enzymatic or chemical processes. However, natural polymers present poor mechanical strength, which frequently makes the manipulation processes difficult. Recent advances in biofabrication, 3D printing, microfluidics, and cell-electrospinning allow the manufacturing of complex natural polymer matrixes with biophysical and structural properties similar to those of the extracellular matrix. In addition, these techniques offer the possibility of incorporating different cell lines into the fabrication process, a revolutionary strategy broadly explored in recent years to produce cell-laden scaffolds that can better mimic the properties of functional tissues. In this review, the use of 3D printing, microfluidics, and electrospinning approaches has been extensively investigated for the biofabrication of naturally derived polymer scaffolds with encapsulated cells intended for biomedical applications (e.g., cell therapies, bone and dental grafts, cardiovascular or musculoskeletal tissue regeneration, and wound healing).eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6208
dc.identifier.urihttps://doi.org/10.34657/5255
dc.language.isoengeng
dc.publisherBasel : MDPIeng
dc.relation.doihttps://doi.org/10.3390/polym13081209
dc.relation.essn2073-4360
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc540eng
dc.subject.otherbiofabricationeng
dc.subject.othermicrofluidicseng
dc.subject.otherelectrospinningeng
dc.subject.other3D printingeng
dc.subject.otherelectrosprayingeng
dc.subject.othernatural polymerseng
dc.subject.othercell encapsulationeng
dc.titleEmerging Biofabrication Techniques : A Review on Natural Polymers for Biomedical Applicationseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorINMeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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