Multifunctional-high resolution imaging plate based on hydrophilic graphene for digital pathology
dc.bibliographicCitation.firstPage | 505101 | |
dc.bibliographicCitation.issue | 50 | |
dc.bibliographicCitation.journalTitle | Nanotechnology | eng |
dc.bibliographicCitation.volume | 33 | |
dc.contributor.author | Lee, Geonhee | |
dc.contributor.author | Oh, Yuna | |
dc.contributor.author | Nam, Jung Tae | |
dc.contributor.author | Ji, Seulgi | |
dc.contributor.author | Jang, A.-Rang | |
dc.contributor.author | Jeong, Du Won | |
dc.contributor.author | Kang, MinSoung | |
dc.contributor.author | Lee, Sun Sook | |
dc.contributor.author | Chae, Soosang | |
dc.contributor.author | Cho, Donghwi | |
dc.contributor.author | Hwang, Jun Yeon | |
dc.contributor.author | Lee, Kyungeun | |
dc.contributor.author | Lee, Jeong-O. | |
dc.date.accessioned | 2023-02-08T07:13:19Z | |
dc.date.available | 2023-02-08T07:13:19Z | |
dc.date.issued | 2022 | |
dc.description.abstract | In the present study, we showed that hydrophilic graphene can serve as an ideal imaging plate for biological specimens. Graphene being a single-atom-thick semi-metal with low secondary electron emission, array tomography analysis of serial sections of biological specimens on a graphene substrate showed excellent image quality with improved z-axis resolution, without including any conductive surface coatings. However, the hydrophobic nature of graphene makes the placement of biological specimens difficult; graphene functionalized with polydimethylsiloxane oligomer was fabricated using a simple soft lithography technique and then processed with oxygen plasma to provide hydrophilic graphene with minimal damage to graphene. High-quality scanning electron microscopy images of biological specimens free from charging effects or distortion were obtained, and the optical transparency of graphene enabled fluorescence imaging of the specimen; high-resolution correlated electron and light microscopy analysis of the specimen became possible with the hydrophilic graphene plate. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/11342 | |
dc.identifier.uri | http://dx.doi.org/10.34657/10376 | |
dc.language.iso | eng | |
dc.publisher | Bristol : IOP Publ. | |
dc.relation.doi | https://doi.org/10.1088/1361-6528/ac9143 | |
dc.relation.essn | 1361-6528 | |
dc.relation.issn | 0957-4484 | |
dc.rights.license | CC BY 4.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject.ddc | 530 | |
dc.subject.other | correlative light and electron microscopy (CLEM) | eng |
dc.subject.other | graphene | eng |
dc.subject.other | polydimethylsiloxane (PDMS) | eng |
dc.subject.other | scanning electron microscope (SEM) | eng |
dc.title | Multifunctional-high resolution imaging plate based on hydrophilic graphene for digital pathology | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | |
wgl.contributor | IPF | |
wgl.subject | Physik | ger |
wgl.type | Zeitschriftenartikel | ger |
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