Bioactive Nanogels Mimicking the Antithrombogenic Nitric Oxide-Release Function of the Endothelium

dc.bibliographicCitation.articleNumber2205185
dc.bibliographicCitation.firstPage2205185
dc.bibliographicCitation.issue14
dc.bibliographicCitation.volume19
dc.contributor.authorHosseinnejad, Aisa
dc.contributor.authorLudwig, Nadine
dc.contributor.authorMersmann, Sina
dc.contributor.authorWinnerbach, Patrick
dc.contributor.authorBleilevens, Christian
dc.contributor.authorRossaint, Rolf
dc.contributor.authorRossaint, Jan
dc.contributor.authorSingh, Smriti
dc.date.accessioned2023-02-10T07:33:38Z
dc.date.available2023-02-10T07:33:38Z
dc.date.issued2023
dc.description.abstractNitric oxide (NO) plays a significant role in controlling the physiology and pathophysiology of the body, including the endothelial antiplatelet function and therefore, antithrombogenic property of the blood vessels. This property of NO can be exploited to prevent thrombus formation on artificial surfaces like extracorporeal membrane oxygenators, which when come into contact with blood lead to protein adsorption and thereby platelet activation causing thrombus formation. However, NO is extremely reactive and has a very short biological half-life in blood, so only endogenous generation of NO from the blood contacting material can result into a stable and kinetically controllable local delivery of NO. In this regards, highly hydrophilic bioactive nanogels are presented which can endogenously generate NO in blood plasma from endogenous NO-donors thereby maintaining a physiological NO flux. It is shown that NO releasing nanogels could initiate cGMP-dependent protein kinase signaling followed by phosphorylation of vasodilator-stimulated phosphoprotein in platelets. This prevents platelet activation and aggregation even in presence of highly potent platelet activators like thrombin, adenosine 5′-diphosphate, and U46619 (thromboxane A2 mimetic).eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11371
dc.identifier.urihttp://dx.doi.org/10.34657/10405
dc.language.isoeng
dc.publisherWeinheim : Wiley-VCH
dc.relation.doihttps://doi.org/10.1002/smll.202205185
dc.relation.essn1613-6829
dc.relation.ispartofseriesSmall : nano micro 19 (2023), Nr. 14
dc.relation.issn1613-6810
dc.rights.licenseCC BY-NC 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.subjectantithrombogeniceng
dc.subjectcGMP-PKG signalingeng
dc.subjectnanogelseng
dc.subjectnitric oxideeng
dc.subjectplatelets inhibitioneng
dc.subject.ddc570
dc.subject.ddc620
dc.titleBioactive Nanogels Mimicking the Antithrombogenic Nitric Oxide-Release Function of the Endotheliumeng
dc.typearticle
dc.typeText
dcterms.bibliographicCitation.journalTitleSmall : nano micro
tib.accessRightsopenAccess
wgl.contributorDWI
wgl.subjectBiowissenschaften/Biologieger
wgl.subjectIngenieurwissenschaftenger
wgl.typeZeitschriftenartikelger
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