Hyperspectral Imaging of Wounds Reveals Augmented Tissue Oxygenation following Cold Physical Plasma Treatment in Vivo

dc.bibliographicCitation.firstPage412
dc.bibliographicCitation.issue3
dc.bibliographicCitation.journalTitleIEEE Transactions on Radiation and Plasma Medical Scienceseng
dc.bibliographicCitation.lastPage419
dc.bibliographicCitation.volume5
dc.contributor.authorSchmidt, Anke
dc.contributor.authorNiesner, Felix
dc.contributor.authorvon Woedtke, Thomas
dc.contributor.authorBekeschus, Sander
dc.date.accessioned2023-05-25T10:24:56Z
dc.date.available2023-05-25T10:24:56Z
dc.date.issued2021
dc.description.abstractEfficient vascularization of skin tissue supports wound healing in response to injury. This includes elevated blood circulation, tissue oxygenation, and perfusion. Cold physical plasma promotes wound healing in animal models and humans. Physical plasmas are multicomponent systems that generate several physicochemical effectors, such as ions, electrons, reactive oxygen and nitrogen species, and UV radiation. However, the consequences of plasma treatment on wound oxygenation and perfusion, vital processes to promote tissue regeneration, are largely unexplored. We used a novel hyperspectral imaging (HSI) system and a murine dermal full-thickness wound model in combination with kINPen argon plasma jet treatment to address this question. Plasma treatment promoted tissue oxygenation in superficial as well as deep (6 mm) layers of wound tissue. In addition to perfusion changes, we found a wound healing stage-dependent shift of tissue hemoglobin and tissue water index during reactive species-driven wound healing. Contactless, fast monitoring of medical parameters in real-time using HSI revealed a plasma-supporting effect in wound healing together with precise information about biological surface-specific features.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/12177
dc.identifier.urihttp://dx.doi.org/10.34657/11209
dc.language.isoeng
dc.publisherNew York, NY : IEEE
dc.relation.doihttps://doi.org/10.1109/trpms.2020.3009913
dc.relation.essn2469-7311
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc610
dc.subject.otherFull-thickness skin woundseng
dc.subject.othermouse modeleng
dc.subject.otherplasma medicineeng
dc.subject.otherreactive oxygen and nitrogen specieseng
dc.subject.otherskin microcirculationeng
dc.titleHyperspectral Imaging of Wounds Reveals Augmented Tissue Oxygenation following Cold Physical Plasma Treatment in Vivoeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorINP
wgl.subjectMedizin, Gesundheitger
wgl.typeZeitschriftenartikelger
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