Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles

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dc.bibliographicCitation.firstPage2830eng
dc.bibliographicCitation.lastPage2839eng
dc.bibliographicCitation.volume15eng
dc.contributor.authorDo, Hoang Huy
dc.contributor.authorUllah, Saif
dc.contributor.authorVillinger, Alexander
dc.contributor.authorLecka, Joanna
dc.contributor.authorSévigny, Jean
dc.contributor.authorEhlers, Peter
dc.contributor.authorIqbal, Jamshed
dc.contributor.authorLanger, Peter
dc.date.accessioned2021-09-03T06:33:15Z
dc.date.available2021-09-03T06:33:15Z
dc.date.issued2019
dc.description.abstractA two-step palladium-catalyzed procedure based on Suzuki–Miyaura cross coupling, followed by a double Buchwald–Hartwig reaction, allows for the synthesis of pharmaceutically relevant benzo[4,5]furo[3,2-b]indoles in moderate to very good yield. The synthesized compounds have been analyzed with regard to their inhibitory activity (IC50) of nucleotide pyrophosphatases h-NPP1 and h-NPP3. The activity lies in the nanomolar range. The results were rationalized based on docking studies. © 2019 Do et al.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6686
dc.identifier.urihttps://doi.org/10.34657/5733
dc.language.isoengeng
dc.publisherFrankfurt, Main : Beilstein-Institut zur Förderung der Chemischen Wissenschafteneng
dc.relation.doihttps://doi.org/10.3762/bjoc.15.276
dc.relation.essn1860-5397
dc.relation.ispartofseriesBeilstein journal of organic chemistry 15 (2019)eng
dc.relation.issn2195-951X
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectBuchwald–Hartwig reactioneng
dc.subjectCyclizationeng
dc.subjectN-heterocycleseng
dc.subjectPalladiumeng
dc.subjectSuzuki–Miyaura reactioneng
dc.subject.ddc540eng
dc.titlePalladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoleseng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleBeilstein journal of organic chemistryeng
tib.accessRightsopenAccesseng
wgl.contributorLIKATeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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