Complexing Methylene Blue with Phosphorus Dendrimers to Increase Photodynamic Activity

dc.bibliographicCitation.firstPage345
dc.bibliographicCitation.issue3
dc.bibliographicCitation.journalTitleMolecules : a journal of synthetic chemistry and natural product chemistryeng
dc.bibliographicCitation.volume22
dc.contributor.authorDabrzalska, Monika
dc.contributor.authorJanaszewska, Anna
dc.contributor.authorZablocka, Maria
dc.contributor.authorMignani, Serge
dc.contributor.authorMajoral, Jean Pierre
dc.contributor.authorKlajnert-Maculewicz, Barbara
dc.date.accessioned2023-01-25T09:58:49Z
dc.date.available2023-01-25T09:58:49Z
dc.date.issued2017
dc.description.abstractThe efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading capacity. The goal of the study was to check whether an anionic phosphorus dendrimer is suitable as a carrier of a photosensitizer—methylene blue (MB). As a biological model, basal cell carcinoma cell lines were used. We checked the influence of the MB complexation on its singlet oxygen production ability using a commercial fluorescence probe. Next, cellular uptake, phototoxicity, reactive oxygen species (ROS) generation, and cell death were investigated. The MB-anionic dendrimer complex (MB-1an) was found to generate less singlet oxygen; however, the complex showed higher cellular uptake and phototoxicity against basal cell carcinoma cell lines, which was accompanied with enhanced ROS production. Owing to the obtained results, we conclude that the photodynamic activity of MB complexed with an anionic dendrimer is higher than free MB against basal cell carcinoma cell lines.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11060
dc.identifier.urihttp://dx.doi.org/10.34657/10086
dc.language.isoeng
dc.publisherBasel : MDPI
dc.relation.doihttps://doi.org/10.3390/molecules22030345
dc.relation.essn1420-3049
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc540
dc.subject.otherBasal cell carcinomaeng
dc.subject.otherMethylene blueeng
dc.subject.otherNanocarriereng
dc.subject.otherPhosphorus dendrimereng
dc.subject.otherPhotodynamic therapyeng
dc.subject.otherPhotosensitizereng
dc.subject.otherPhototoxicityeng
dc.titleComplexing Methylene Blue with Phosphorus Dendrimers to Increase Photodynamic Activityeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorIPF
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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