Graphene oxide functional nanohybrids with magnetic nanoparticles for improved vectorization of doxorubicin to neuroblastoma cells
dc.bibliographicCitation.firstPage | 3 | eng |
dc.bibliographicCitation.issue | 1 | eng |
dc.bibliographicCitation.journalTitle | Pharmaceutics | eng |
dc.bibliographicCitation.lastPage | 182 | eng |
dc.bibliographicCitation.volume | 11 | eng |
dc.contributor.author | Lerra, L. | |
dc.contributor.author | Farfalla, A. | |
dc.contributor.author | Sanz, B. | |
dc.contributor.author | Cirillo, G. | |
dc.contributor.author | Vittorio, O. | |
dc.contributor.author | Voli, F. | |
dc.contributor.author | Grand, M.L. | |
dc.contributor.author | Curcio, M. | |
dc.contributor.author | Nicoletta, F.P. | |
dc.contributor.author | Dubrovska, A. | |
dc.contributor.author | Hampel, S. | |
dc.contributor.author | Iemma, F. | |
dc.contributor.author | Goya, G.F. | |
dc.date.accessioned | 2020-07-18T06:12:40Z | |
dc.date.available | 2020-07-18T06:12:40Z | |
dc.date.issued | 2019 | |
dc.description.abstract | With the aim to obtain a site-specific doxorubicin (DOX) delivery in neuroblastoma SH-SY5Y cells, we designed an hybrid nanocarrier combining graphene oxide (GO) and magnetic iron oxide nanoparticles (MNPs), acting as core elements, and a curcumin–human serum albumin conjugate as functional coating. The nanohybrid, synthesized by redox reaction between the MNPs@GO system and albumin bioconjugate, consisted of MNPs@GO nanosheets homogeneously coated by the bioconjugate as verified by SEM investigations. Drug release experiments showed a pH-responsive behavior with higher release amounts in acidic (45% at pH 5.0) vs. neutral (28% at pH 7.4) environments. Cell internalization studies proved the presence of nanohybrid inside SH-SY5Y cytoplasm. The improved efficacy obtained in viability assays is given by the synergy of functional coating and MNPs constituting the nanohybrids: while curcumin moieties were able to keep low DOX cytotoxicity levels (at concentrations of 0.44–0.88 µM), the presence of MNPs allowed remote actuation on the nanohybrid by a magnetic field, increasing the dose delivered at the target site. | eng |
dc.description.fonds | Leibniz_Fonds | |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://doi.org/10.34657/3632 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/5003 | |
dc.language.iso | eng | eng |
dc.publisher | Basel : MDPI AG | eng |
dc.relation.doi | https://doi.org/10.3390/pharmaceutics11010003 | |
dc.relation.issn | 1999-4923 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 610 | eng |
dc.subject.other | Graphene oxide | eng |
dc.subject.other | Iron oxide nanoparticles | eng |
dc.subject.other | Magnetic targeting | eng |
dc.subject.other | Nanohybrids | eng |
dc.subject.other | Synergism | eng |
dc.subject.other | albumin | eng |
dc.subject.other | curcumin | eng |
dc.subject.other | doxorubicin | eng |
dc.subject.other | graphene oxide | eng |
dc.subject.other | magnetic iron oxide nanoparticle | eng |
dc.subject.other | magnetic nanoparticle | eng |
dc.subject.other | nanoparticle | eng |
dc.subject.other | unclassified drug | eng |
dc.subject.other | acidity | eng |
dc.subject.other | Article | eng |
dc.subject.other | cell viability | eng |
dc.subject.other | concentration (parameters) | eng |
dc.subject.other | conjugation | eng |
dc.subject.other | controlled study | eng |
dc.subject.other | cytoplasm | eng |
dc.subject.other | drug coating | eng |
dc.subject.other | drug cytotoxicity | eng |
dc.subject.other | drug delivery system | eng |
dc.subject.other | human | eng |
dc.subject.other | human cell | eng |
dc.subject.other | intracellular transport | eng |
dc.subject.other | neuroblastoma cell | eng |
dc.subject.other | reaction analysis | eng |
dc.subject.other | scanning electron microscopy | eng |
dc.subject.other | SH-SY5Y cell line | eng |
dc.subject.other | synthesis | eng |
dc.title | Graphene oxide functional nanohybrids with magnetic nanoparticles for improved vectorization of doxorubicin to neuroblastoma cells | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IFWD | eng |
wgl.subject | Medizin, Gesundheit | eng |
wgl.type | Zeitschriftenartikel | eng |
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