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- ItemWell-posedness for a class of phase-field systems modeling prostate cancer growth with fractional operators and general nonlinearities(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenThis paper deals with a general system of equations and conditions arising from a mathematical model of prostate cancer growth with chemotherapy and antiangiogenic therapy that has been recently introduced and analyzed (see [P. Colli et al., Mathematical analysis and simulation study of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects, Math. Models Methods Appl. Sci. bf 30 (2020), 1253--1295]). The related system includes two evolutionary operator equations involving fractional powers of selfadjoint, nonnegative, unbounded linear operators having compact resolvents. Both equations contain nonlinearities and in particular the equation describing the dynamics of the tumor phase variable has the structure of a Allen--Cahn equation with double-well potential and additional nonlinearity depending also on the other variable, which represents the nutrient concentration. The equation for the nutrient concentration is nonlinear as well, with a term coupling both variables. For this system we design an existence, uniqueness and continuous dependence theory by setting up a careful analysis which allows the consideration of nonsmooth potentials and the treatment of continuous nonlinearities with general growth properties.
- ItemWell-posedness and optimal control for a Cahn--Hilliard--Oono system with control in the mass term(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Colli, Pierluigi; Gilardi, Gianni; Rocca, Elisabetta; Sprekels, JürgenThe paper treats the problem of optimal distributed control of a Cahn--Hilliard--Oono system in Rd, 1 ≤ d ≤ 3 with the control located in the mass term and admitting general potentials that include both the case of a regular potential and the case of some singular potential. The first part of the paper is concerned with the dependence of the phase variable on the control variable. For this purpose, suitable regularity and continuous dependence results are shown. In particular, in the case of a logarithmic potential, we need to prove an ad hoc strict separation property, and for this reason we have to restrict ourselves to the case d = 2. In the rest of the work, we study the necessary first-order optimality conditions, which are proved under suitable compatibility conditions on the initial datum of the phase variable and the time derivative of the control, at least in case of potentials having unbounded domain
- ItemCahn--Hilliard--Brinkman model for tumor growth with possibly singular potentials(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2022) Colli, Pierluigi; Gilardi, Gianni; Signori, Andrea; Sprekels, JürgenWe analyze a phase field model for tumor growth consisting of a Cahn--Hilliard--Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The main novelty of the paper concerns the discussion of the existence of weak solutions to the system covering all the meaningful cases for the nonlinear potentials; in particular, the typical choices given by the regular, the logarithmic, and the double obstacle potentials are admitted in our treatise. Compared to previous results related to similar models, we suggest, instead of the classical no-flux condition, a Dirichlet boundary condition for the chemical potential appearing in the Cahn--Hilliard-type equation. Besides, abstract growth conditions for the source terms that may depend on the solution variables are postulated.
- ItemOptimal control of a phase field system of Caginalp type with fractional operators(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2020) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn their recent work ``Well-posedness, regularity and asymptotic analyses for a fractional phase field system'' (Asymptot. Anal. 114 (2019), 93--128), two of the present authors have studied phase field systems of Caginalp type, which model nonconserved, nonisothermal phase transitions and in which the occurring diffusional operators are given by fractional versions in the spectral sense of unbounded, monotone, selfadjoint, linear operators having compact resolvents. In this paper, we complement this analysis by investigating distributed optimal control problems for such systems. It is shown that the associated control-to-state operator is Fréchet differentiable between suitable Banach spaces, and meaningful first-order necessary optimality conditions are derived in terms of a variational inequality and the associated adjoint state variables.
- ItemAn asymptotic analysis for a generalized Cahn--Hilliard system with fractional operators(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2020) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn a recent paper the same authors have proved existence, uniqueness and regularity results for a class of viscous and nonviscous Cahn--Hilliard systems of two operator equations in which nonlinearities of double-well type, like regular or logarithmic potentials, as well as nonsmooth potentials with indicator functions, were admitted. The operators appearing in the system equations are fractional powers in the spectral sense of general linear operators, which are densely defined, unbounded, selfadjoint, and monotone in the Hilbert space of square-integrable functions on a bounded and smooth three-dimensional domain, and have compact resolvents. Here, for the case of the viscous system, we analyze the asymptotic behavior of the solution as the fractional power coefficient of the second operator tends to zero. We prove convergence to a phase relaxation problem at the limit, and we also investigate this limiting problem, in which an additional term containing the projection of the phase variable on the kernel of the second operator appears.