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Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
2020, Schirmer, Lucas, Hoornaert, ChloƩ, Le Blon, Debbie, Eigel, Dimitri, Neto, Catia, Gumbleton, Mark, Welzel, Petra B., Rosser, Anne E., Werner, Carsten, Ponsaerts, Peter, Newland, Ben
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. Ā© 2020 The Royal Society of Chemistry.
Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: Implications for cell transplantation
2018, Newland, Heike, Eigel, Dimitri, Rosser, Anne E., Werner, Carsten, Newland, Ben
This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16-20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the spheres rescue SH-SY5Y cells and meschymal stem cells, showing that oxygen producing biomaterials may hold potential to improve the survival of cells post-transplantation.