Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Loading...
Date
2020
Volume
8
Issue
18
Journal
Biomaterials science
Series Titel
Book Title
Publisher
Cambridge : Royal Soc. of Chemistry
Link to publishers version
Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry.
Description
Keywords
Citation
Schirmer, L., Hoornaert, C., Le Blon, D., Eigel, D., Neto, C., Gumbleton, M., et al. (2020). Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain (Cambridge : Royal Soc. of Chemistry). Cambridge : Royal Soc. of Chemistry. https://doi.org//10.1039/d0bm01249a
Collections
License
CC BY 3.0 Unported