Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
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Volume
8
Issue
18
Journal
Biomaterials science
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Cambridge : Royal Soc. of Chemistry
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Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry.
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Keywords
Anti-inflammatories, Controlled delivery, Cryogels, Immuno modulations, Interleukin-13, Microcarriers, Myeloid cells, Up-regulation, Polysaccharides, cryogel, glial fibrillary acidic protein, heparin, interleukin 13, major histocompatibility antigen class 2, adult, animal cell, animal experiment, animal tissue, Article, bone marrow cell, controlled drug release, controlled study, drug delivery system, gene expression, immune response, immunohistochemistry, immunomodulation, in vitro study, in vivo study, intrastriatal drug administration, macrophage activation, microglia, mouse, nonhuman, priority journal, upregulation
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Article
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publishedVersion
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CC BY 3.0 Unported