Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

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dc.bibliographicCitation.firstPage4997eng
dc.bibliographicCitation.issue18eng
dc.bibliographicCitation.journalTitleBiomaterials scienceeng
dc.bibliographicCitation.lastPage5004eng
dc.bibliographicCitation.volume8eng
dc.contributor.authorSchirmer, Lucas
dc.contributor.authorHoornaert, Chloé
dc.contributor.authorLe Blon, Debbie
dc.contributor.authorEigel, Dimitri
dc.contributor.authorNeto, Catia
dc.contributor.authorGumbleton, Mark
dc.contributor.authorWelzel, Petra B.
dc.contributor.authorRosser, Anne E.
dc.contributor.authorWerner, Carsten
dc.contributor.authorPonsaerts, Peter
dc.contributor.authorNewland, Ben
dc.date.accessioned2021-09-14T08:54:50Z
dc.date.available2021-09-14T08:54:50Z
dc.date.issued2020
dc.description.abstractInterleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6793
dc.identifier.urihttps://doi.org/10.34657/5840
dc.language.isoengeng
dc.publisherCambridge : Royal Soc. of Chemistryeng
dc.relation.doihttps://doi.org/10.1039/d0bm01249a
dc.relation.essn2047-4849
dc.relation.issn2047-4830
dc.rights.licenseCC BY 3.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/eng
dc.subject.ddc540eng
dc.subject.otherAnti-inflammatorieseng
dc.subject.otherControlled deliveryeng
dc.subject.otherCryogelseng
dc.subject.otherImmuno modulationseng
dc.subject.otherInterleukin-13eng
dc.subject.otherMicrocarrierseng
dc.subject.otherMyeloid cellseng
dc.subject.otherUp-regulationeng
dc.subject.otherPolysaccharideseng
dc.subject.othercryogeleng
dc.subject.otherglial fibrillary acidic proteineng
dc.subject.otherheparineng
dc.subject.otherinterleukin 13eng
dc.subject.othermajor histocompatibility antigen class 2eng
dc.subject.otheradulteng
dc.subject.otheranimal celleng
dc.subject.otheranimal experimenteng
dc.subject.otheranimal tissueeng
dc.subject.otherArticleeng
dc.subject.otherbone marrow celleng
dc.subject.othercontrolled drug releaseeng
dc.subject.othercontrolled studyeng
dc.subject.otherdrug delivery systemeng
dc.subject.othergene expressioneng
dc.subject.otherimmune responseeng
dc.subject.otherimmunohistochemistryeng
dc.subject.otherimmunomodulationeng
dc.subject.otherin vitro studyeng
dc.subject.otherin vivo studyeng
dc.subject.otherintrastriatal drug administrationeng
dc.subject.othermacrophage activationeng
dc.subject.othermicrogliaeng
dc.subject.othermouseeng
dc.subject.othernonhumaneng
dc.subject.otherpriority journaleng
dc.subject.otherupregulationeng
dc.titleHeparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the braineng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIPFeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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