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- ItemA boundary control problem for the pure Cahn–Hilliard equation with dynamic boundary conditions(Berlin ; Boston, Mass. : de Gruyter, 2015) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenA boundary control problem for the pure Cahn–Hilliard equations with possibly singular potentialsand dynamic boundary conditions is studied and rst-order necessary conditions for optimality are proved.
- ItemDistributed optimal control of a nonstandard nonlocal phase field system(Springfield, MO : AIMS Press, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenWe investigate a distributed optimal control problem for a nonlocal phase field model of viscous Cahn-Hilliard type. The model constitutes a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of diffusion that has been studied in a series of papers by P. Podio-Guidugli and the present authors. The model consists of a highly nonlinear parabolic equation coupled to an ordinary differential equation. The latter equation contains both nonlocal and singular terms that render the analysis difficult. Standard arguments of optimal control theory do not apply directly, although the control constraints and the cost functional are of standard type. We show that the problem admits a solution, and we derive the first-order necessary conditions of optimality.
- ItemA distributed control problem for a fractional tumor growth model(Basel : MDPI, 2019) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn this paper, we study the distributed optimal control of a system of three evolutionary equations involving fractional powers of three self-adjoint, monotone, unbounded linear operators having compact resolvents. The system is a generalization of a Cahn-Hilliard type phase field system modeling tumor growth that has been proposed by Hawkins-Daarud, van der Zee and Oden. The aim of the control process, which could be realized by either administering a drug or monitoring the nutrition, is to keep the tumor cell fraction under control while avoiding possible harm for the patient. In contrast to previous studies, in which the occurring unbounded operators governing the diffusional regimes were all given by the Laplacian with zero Neumann boundary conditions, the operators may in our case be different; more generally, we consider systems with fractional powers of the type that were studied in a recent work by the present authors. In our analysis, we show the Fréchet differentiability of the associated control-to-state operator, establish the existence of solutions to the associated adjoint system, and derive the first-order necessary conditions of optimality for a cost functional of tracking type. © 2019 by the authors.
- ItemWell-posedness and regularity for a fractional tumor growth model(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field system of Cahn--Hilliard type modelling tumor growth that has been proposed in Hawkins-Daarud et al. (Int. J. Numer. Math. Biomed. Eng. 28 (2012), 3--24) and investigated in recent papers co-authored by the present authors and E. Rocca. The model consists of a Cahn--Hilliard equation for the tumor cell fraction φ, coupled to a reaction-diffusion equation for a function S representing the nutrient-rich extracellular water volume fraction. Effects due to fluid motion are neglected. The generalization investigated in this paper is motivated by the possibility that the diffusional regimes governing the evolution of the different constituents of the model may be of different (e.g., fractional) type. Under rather general assumptions, well-posedness and regularity results are shown. In particular, by writing the equation governing the evolution of the chemical potential in the form of a general variational inequality, also singular or nonsmooth constributions of logarithmic or of double obstacle type to the energy density can be admitted.
- ItemAn asymptotic analysis for a generalized Cahn–Hilliard system with fractional operators(Basel : Springer, 2021) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn the recent paper “Well-posedness and regularity for a generalized fractional Cahn–Hilliard system” (Colli et al. in Atti Accad Naz Lincei Rend Lincei Mat Appl 30:437–478, 2019), the same authors have studied viscous and nonviscous Cahn–Hilliard systems of two operator equations in which nonlinearities of double-well type, like regular or logarithmic potentials, as well as nonsmooth potentials with indicator functions, were admitted. The operators appearing in the system equations are fractional powers A2r and B2σ (in the spectral sense) of general linear operators A and B, which are densely defined, unbounded, selfadjoint, and monotone in the Hilbert space L2(Ω), for some bounded and smooth domain Ω⊂R3, and have compact resolvents. Existence, uniqueness, and regularity results have been proved in the quoted paper. Here, in the case of the viscous system, we analyze the asymptotic behavior of the solution as the parameter σ appearing in the operator B2σ decreasingly tends to zero. We prove convergence to a phase relaxation problem at the limit, and we also investigate this limiting problem, in which an additional term containing the projection of the phase variable on the kernel of B appears.
- ItemOn a Cahn-Hilliard system with convection and dynamic boundary conditions(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2017) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenThis paper deals with an initial and boundary value problem for a system coupling equation and boundary condition both of CahnHilliard type; an additional convective term with a forced velocity field, which could act as a control on the system, is also present in the equation. Either regular or singular potentials are admitted in the bulk and on the boundary. Both the viscous and pure CahnHilliard cases are investigated, and a number of results is proven about existence of solutions, uniqueness, regularity, continuous dependence, uniform boundedness of solutions, strict separation property. A complete approximation of the problem, based on the regularization of maximal monotone graphs and the use of a FaedoGalerkin scheme, is introduced and rigorously discussed.
- ItemDistributed optimal control of a nonstandard nonlocal phase field system(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenWe investigate a distributed optimal control problem for a nonlocal phase field model of viscous Cahn-Hilliard type. The model constitutes a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of diffusion that has been studied in a series of papers by P. Podio-Guidugli and the present authors. The model consists of a highly nonlinear parabolic equation coupled to an ordinary differential equation. The latter equation contains both nonlocal and singular terms that render the analysis difficult. Standard arguments of optimal control theory do not apply directly, although the control constraints and the cost functional are of standard type. We show that the problem admits a solution, and we derive the first-order necessary conditions of optimality.
- ItemGlobal existence for a nonstandard viscous Cahn-Hilliard system with dynamic boundary condition(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn this paper, we study a model for phase segregation taking place in a spatial domain that was introduced by Podio-Guidugli in Ric. Mat. 55 (2006), pp. 105-118. The model consists of a strongly coupled system of nonlinear parabolic differential equations, in which products between the unknown functions and their time derivatives occur that are difficult to handle analytically. In contrast to the existing literature about this PDE system, we consider here a dynamic boundary condition involving the Laplace-Beltrami operator for the order parameter. This boundary condition models an additional nonconserving phase transition occurring on the surface of the domain. Different well-posedness results are shown, depending on the smoothness properties of the involved bulk and surface free energies.
- ItemDistributed optimal control of a nonstandard nonlocal phase field system with double obstacle potential(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenThis paper is concerned with a distributed optimal control problem for a nonlocal phase field model of CahnHilliard type, which is a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of diffusion. The local model has been investigated in a series of papers by P. Podio-Guidugli and the present authors the nonlocal model studied here consists of a highly nonlinear parabolic equation coupled to an ordinary differential inclusion of subdifferential type. The inclusion originates from a free energy containing the indicator function of the interval in which the order parameter of the phase segregation attains its values. It also contains a nonlocal term modeling long-range interactions. Due to the strong nonlinear couplings between the state variables (which even involve products with time derivatives), the analysis of the state system is difficult. In addition, the presence of the differential inclusion is the reason that standard arguments of optimal control theory cannot be applied to guarantee the existence of Lagrange multipliers. In this paper, we employ recent results proved for smooth logarithmic potentials and perform a so-called deep quench approximation to establish existence and first-order necessary optimality conditions for the nonsmooth case of the double obstacle potential.
- ItemOptimal boundary control of a nonstandard viscous Cahn-Hilliard system with dynamic boundary condition(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn this paper, we study an optimal boundary control problem for a model for phase separation taking place in a spatial domain that was introduced by Podio-Guidugli in Ric. Mat. 55 (2006), pp. 105118. The model consists of a strongly coupled system of nonlinear parabolic differential equations, in which products between the unknown functions and their time derivatives occur that are difficult to handle analytically. In contrast to the existing control literature about this PDE system, we consider here a dynamic boundary condition involving the Laplace-Beltrami operator for the order parameter of the system, which models an additional nonconserving phase transition occurring on the surface of the domain. We show the Fréchet differentiability of the associated control-to-state operator in appropriate Banach spaces and derive results on the existence of optimal controls and on first-order necessary optimality conditions in terms of a variational inequality and the adjoint state system.