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Author: Wu, Fu-Peng × WGL Institute: LIKAT ×

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Now showing 1 - 4 of 4
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    Rhodium-catalyzed borylative carbon monoxide reduction to gem-diborylmethane
    (Amsterdam [u.a.] : Elsevier, 2021) Xua, Jian-Xing; Wu, Fu-Peng; Wu, Xiao-Feng
    Herein, we developed a rhodium-catalyzed reduction of CO with bis(pinacolato)diboron (B2pin2) under atmospheric pressure of CO with silane as the hydride source, gem-diborylmethane [H2C(Bpin)2] as a versatile and fundamental C1 compound can be formed. Notably, this is the first example on transition metal-catalyzed borylation of CO. © 2020 The Author(s)
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    Pd/Cu-Catalyzed amide-enabled selectivity-reversed borocarbonylation of unactivated alkenes
    (Cambridge : RSC, 2021) Wu, Fu-Peng; Wu, Xiao-Feng
    The addition reaction between CuBpin and alkenes to give a terminal boron substituted intermediate is usually fast and facile. In this communication, a selectivity-reversed procedure has been designed and established. This selectivity-reversed borocarbonylation reaction is enabled by a cooperative action between palladium and copper catalysts and proceeds with complete regioselectivity. The key to the success of this transformation is the coordination of the amide group and slower CuBpin formation by using KHCO3as the base. A wide range of β-boryl ketones were produced from terminal unactivated aliphatic alkenes and aryl iodides. Further synthetic transformations of the obtained β-boryl ketones have been developed as well. © The Royal Society of Chemistry 2021.
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    Direct synthesis of benzylic amines by palladium-catalyzed carbonylative aminohomologation of aryl halides
    ([London] : Macmillan Publishers Limited, part of Springer Nature, 2018) Peng, Jin-Bao; Wu, Fu-Peng; Xu, Cong; Qi, Xinxin; Ying, Jun; Wu, Xiao-Feng
    Benzylic amines are valuable compounds with important applications in areas including pharmaceuticals and agrochemicals. The known procedures for their synthesis are limited by difficulties in functionalizing the parent aminomethyl groups. On the other hand, carbonylation reactions offer a potent method to introduce carbonyl groups and homologate carbon chains. However, carbonylative aminohomologation of aryl halides is challenging due to competing reactions and the need to balance multiple sequential steps. Here we report a palladium-catalyzed carbonylative aminohomologation reaction for the direct aminomethylation of aryl halides. The reaction proceeds via a tandem palladium-catalyzed formylation, followed by imine formation and formic acid-mediated reduction. Useful functional groups including chloride, bromide, ester, ketone, nitro, and cyano are compatible with this reaction. Both aryl iodides and bromides are suitable substrates and a wide range of synthetically useful amines are efficiently obtained in moderate to excellent yields.
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    Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes: synthesis of β-geminal-diboryl ketones
    (Beijing : Science China Press, 2021) Yuan, Yang; Wu, Fu-Peng; Spannenberg, Anke; Wu, Xiao-Feng
    Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis. Herein, we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes. This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance. Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes.