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Start date: 2021 Γ— End date: 2023 Γ— Start date: 2020 Γ— DDC: 570 Γ— DDC: 610 Γ— WGL Institute: IFWD Γ—

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    Release of Bioactive Molecules from Graphene Oxide-Alginate Hybrid Hydrogels: Effect of Crosslinking Method
    (Basel : MDPI, 2023) Madeo, Lorenzo Francesco; Curcio, Manuela; Iemma, Francesca; Nicoletta, Fiore Pasquale; Hampel, Silke; Cirillo, Giuseppe
    To investigate the influence of crosslinking methods on the releasing performance of hybrid hydrogels, we synthesized two systems consisting of Graphene oxide (GO) as a functional element and alginate as polymer counterpart by means of ionic gelation (physical method, π»π‘ƒπ΄βˆ’πΊπ‘‚) and radical polymerization (chemical method, π»πΆπ΄βˆ’πΊπ‘‚). Formulations were optimized to maximize the GO content (2.0 and 1.15% for π»π‘ƒπ΄βˆ’πΊπ‘‚ and π»πΆπ΄βˆ’πΊπ‘‚, respectively) and Curcumin (CUR) was loaded as a model drug at 2.5, 5.0, and 7.5% (by weight). The physico-chemical characterization confirmed the homogeneous incorporation of GO within the polymer network and the enhanced thermal stability of hybrid vs. blank hydrogels. The determination of swelling profiles showed a higher swelling degree for π»πΆπ΄βˆ’πΊπ‘‚ and a marked pH responsivity due to the COOH functionalities. Moreover, the application of external voltages modified the water affinity of π»πΆπ΄βˆ’πΊπ‘‚, while they accelerated the degradation of π»π‘ƒπ΄βˆ’πΊπ‘‚ due to the disruption of the crosslinking points and the partial dissolution of alginate. The evaluation of release profiles, extensively analysed by the application of semi-empirical mathematical models, showed a sustained release from hybrid hydrogels, and the possibility to modulate the releasing amount and rate by electro-stimulation of π»πΆπ΄βˆ’πΊπ‘‚.
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    Carbon Nanohorns as Effective Nanotherapeutics in Cancer Therapy
    (Basel : MDPI, 2021) Curcio, M.; Cirillo, G.; Saletta, F.; Michniewicz, F.; Nicoletta, F.; Vittorio, O.; Hampel, S.; Iemma, F.
    Different carbon nanostructures have been explored as functional materials for the development of effective nanomaterials in cancer treatment applications. This review mainly aims to discuss the features, either strength or weakness, of carbon nanohorn (CNH), carbon conical horn-shaped nanostructures of sp2 carbon atoms. The interest for these materials arises from their ability to couple the clinically relevant properties of carbon nanomaterials as drug carriers with the negligible toxicity described in vivo. Here, we offer a comprehensive overview of the recent advances in the use of CNH in cancer treatments, underlining the benefits of each functionalization route and approach, as well as the biological performances of either loaded and unloaded materials, while discussing the importance of delivery devices.