2019, Formicola, Beatrice, Dal, Magro, Roberta, Montefusco-Pereira, Carlos V., Lehr, Claus‑Michael, Koch, Marcus, Russo, Laura, Grasso, Gianvito, Deriu, Marco A., Danani, Andrea, Bourdoulous, Sandrine, Re, Francesca

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s).