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High-throughput screening Raman microspectroscopy for assessment of drug-induced changes in diatom cells
2019, Rüger J., Mondol A.S., Schie I.W., Popp J., Krafft C.
High-throughput screening Raman spectroscopy (HTS-RS) with automated localization algorithms offers unsurpassed speed and sensitivity to investigate the effect of dithiothreitol on the diatom Phaedactylum tricornutum. The HTS-RS capability that was demonstrated for this model system can be transferred to unmet analytical applications such as kinetic in vivo studies of microalgal assemblages. © 2019 The Royal Society of Chemistry.