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DDC: 540 × Subject: Biodegradable polymers × Subject: Nanoparticles × WGL Institute: IPF ×

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    Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles
    (Brookfield, Conn. : Society of Plastic Engineers, 2019) Folini, Jenny; Huang, Chao-Hung; Anderson, James C.; Meier, Wolfgang P.; Gaitzsch, Jens
    Responsive and biodegradable nanoparticles are essential for functional drug delivery systems. We herein report the first pH sensitive polyester from radical ring-opening polymerisation of novel amine-bearing cyclic ketene acetals (CKAs). The CKAs were synthesised via an intermediate carbonate and the resulting polyesters showed a pKa around pH 6. Together with an initial application in biodegradable nanoparticles, they open the pathway for a new generation of functional polyesters.