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- ItemThe Berlin principles on one health - Bridging global health and conservation(Amsterdam [u.a.] : Elsevier Science, 2020) Gruetzmacher, Kim; Karesh, William B.; Amuasi, John H.; Arshad, Adnan; Farlow, Andrew; Gabrysch, Sabine; Jetzkowitz, Jens; Lieberman, Susan; Palmer, Clare; Winkler, Andrea S.; Walzer, ChrisFor over 15-years, proponents of the One Health approach have worked to consistently interweave components that should never have been separated and now more than ever need to be re-connected: the health of humans, non-human animals, and ecosystems. We have failed to heed the warning signs. A One Health approach is paramount in directing our future health in this acutely and irrevocably changed world. COVID-19 has shown us the exorbitant cost of inaction. The time to act is now. © 2020
- ItemLimiting global warming to 1.5 °C will lower increases in inequalities of four hazard indicators of climate change(Bristol : IOP Publ., 2019) Shiogama, Hideo; Hasegawa, Tomoko; Fujimori, Shinichiro; Murakami, Daisuke; Takahashi, Kiyoshi; Tanaka, Katsumasa; Emori, Seita; Kubota, Izumi; Abe, Manabu; Imada, Yukiko; Watanabe, Masahiro; Mitchell, Daniel; Schaller, Nathalie; Sillmann, Jana; Fischer, Erich M.; Scinocca, John F.; Bethke, Ingo; Lierhammer, Ludwig; Takakura, Jun’ya; Trautmann, Tim; Döll, Petra; Ostberg, Sebastian; Müller Schmied, Hannes; Saeed, Fahad; Schleussner, Carl-FriedrichClarifying characteristics of hazards and risks of climate change at 2 °C and 1.5 °C global warming is important for understanding the implications of the Paris Agreement. We perform and analyze large ensembles of 2 °C and 1.5 °C warming simulations. In the 2 °C runs, we find substantial increases in extreme hot days, heavy rainfalls, high streamflow and labor capacity reduction related to heat stress. For example, about half of the world's population is projected to experience a present day 1-in-10 year hot day event every other year at 2 °C warming. The regions with relatively large increases of these four hazard indicators coincide with countries characterized by small CO2 emissions, low-income and high vulnerability. Limiting global warming to 1.5 °C, compared to 2 °C, is projected to lower increases in the four hazard indicators especially in those regions.
- ItemCascading Hazards in the Aftermath of Australia's 2019/2020 Black Summer Wildfires(Hoboken, NJ : Wiley-Blackwell, 2021) Kemter, M.; Fischer, M.; Luna, L.V.; Schönfeldt, E.; Vogel, J.; Banerjee, A.; Korup, O.; Thonicke, K.Following an unprecedented drought, Australia's 2019/2020 “Black Summer” fire season caused severe damage, gravely impacting both humans and ecosystems, and increasing susceptibility to other hazards. Heavy precipitation in early 2020 led to flooding and runoff that entrained ash and soil in burned areas, increasing sediment concentration in rivers, and reducing water quality. We exemplify this hazard cascade in a catchment in New South Wales by mapping burn severity, flood, and rainfall recurrence; estimating changes in soil erosion; and comparing them with river turbidity data. We show that following the extreme drought and wildfires, even moderate rain and floods led to undue increases in soil erosion and reductions in water quality. While natural risk analysis and planning commonly focuses on a single hazard, we emphasize the need to consider the entire hazard cascade, and highlight the impacts of ongoing climate change beyond its direct effect on wildfires.
- ItemCascade Synthesis of Pyrroles from Nitroarenes with Benign Reductants Using a Heterogeneous Cobalt Catalyst(Weinheim : Wiley-VCH, 2020) Ryabchuk, Pavel; Leischner, Thomas; Kreyenschulte, Carsten; Spannenberg, Anke; Junge, Kathrin; Beller, MatthiasA bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal–Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodology was demonstrated on a variety of functionalized substrates including the preparation of biologically active and pharmaceutically relevant compounds, for example, (+)-Isamoltane. © 2020 The Authors. Published by Wiley-VCH GmbH
- ItemQuantifying the parameter dependent basin of the unsafe regime of asymmetric Lévy-noise-induced critical transitions(Dordrecht [u.a.] : Springer, 2021) Ma, Jinzhong; Xu, Yong; Li, Yongge; Tian, Ruilan; Ma, Shaojuan; Kurths, J.In real systems, the unpredictable jump changes of the random environment can induce the critical transitions (CTs) between two non-adjacent states, which are more catastrophic. Taking an asymmetric Lévy-noise-induced tri-stable model with desirable, sub-desirable, and undesirable states as a prototype class of real systems, a prediction of the noise-induced CTs from the desirable state directly to the undesirable one is carried out. We first calculate the region that the current state of the given model is absorbed into the undesirable state based on the escape probability, which is named as the absorbed region. Then, a new concept of the parameter dependent basin of the unsafe regime (PDBUR) under the asymmetric Lévy noise is introduced. It is an efficient tool for approximately quantifying the ranges of the parameters, where the noise-induced CTs from the desirable state directly to the undesirable one may occur. More importantly, it may provide theoretical guidance for us to adopt some measures to avert a noise-induced catastrophic CT. © 2021, The Author(s).
- ItemImpact of process temperature and organic loading rate on cellulolytic/hydrolytic biofilm microbiomes during biomethanation of ryegrass silage revealed by genome-centered metagenomics and metatranscriptomics(London : BioMed Central, 2020) Maus, Irena; Klocke, Michael; Derenkó, Jaqueline; Stolze, Yvonne; Beckstette, Michael; Jost, Carsten; Wibberg, Daniel; Blom, Jochen; Henke, Christian; Willenbücher, Katharina; Rumming, Madis; Rademacher, Antje; Pühler, Alfred; Sczyrba, Alexander; Schlüter, AndreasBackground: Anaerobic digestion (AD) of protein-rich grass silage was performed in experimental two-stage two-phase biogas reactor systems at low vs. increased organic loading rates (OLRs) under mesophilic (37 °C) and thermophilic (55 °C) temperatures. To follow the adaptive response of the biomass-attached cellulolytic/hydrolytic biofilms at increasing ammonium/ammonia contents, genome-centered metagenomics and transcriptional profiling based on metagenome assembled genomes (MAGs) were conducted. Results: In total, 78 bacterial and archaeal MAGs representing the most abundant members of the communities, and featuring defined quality criteria were selected and characterized in detail. Determination of MAG abundances under the tested conditions by mapping of the obtained metagenome sequence reads to the MAGs revealed that MAG abundance profiles were mainly shaped by the temperature but also by the OLR. However, the OLR effect was more pronounced for the mesophilic systems as compared to the thermophilic ones. In contrast, metatranscriptome mapping to MAGs subsequently normalized to MAG abundances showed that under thermophilic conditions, MAGs respond to increased OLRs by shifting their transcriptional activities mainly without adjusting their proliferation rates. This is a clear difference compared to the behavior of the microbiome under mesophilic conditions. Here, the response to increased OLRs involved adjusting of proliferation rates and corresponding transcriptional activities. The analysis led to the identification of MAGs positively responding to increased OLRs. The most outstanding MAGs in this regard, obviously well adapted to higher OLRs and/or associated conditions, were assigned to the order Clostridiales (Acetivibrio sp.) for the mesophilic biofilm and the orders Bacteroidales (Prevotella sp. and an unknown species), Lachnospirales (Herbinix sp. and Kineothrix sp.) and Clostridiales (Clostridium sp.) for the thermophilic biofilm. Genome-based metabolic reconstruction and transcriptional profiling revealed that positively responding MAGs mainly are involved in hydrolysis of grass silage, acidogenesis and/or acetogenesis. Conclusions: An integrated-omics approach enabled the identification of new AD biofilm keystone species featuring outstanding performance under stress conditions such as increased OLRs. Genome-based knowledge on the metabolic potential and transcriptional activity of responsive microbiome members will contribute to the development of improved microbiological AD management strategies for biomethanation of renewable biomass. © 2020 The Author(s).
- ItemBroad consent under the GDPR : an optimistic perspective on a bright future(Berlin ; Heidelberg [u.a.] : Springer Open, 2020) Hallinan, DaraBroad consent-the act of gaining one consent for multiple potential future research projects-sits at the core of much current genomic research practice. Since the 25th May 2018, the General Data Protection Regulation (GDPR) has applied as valid law concerning genomic research in the EU and now occupies a dominant position in the legal landscape. Yet, the position of the GDPR concerning broad consent has recently been cause for concern in the genomic research community. Whilst the text of the GDPR apparently supports the practice, recent jurisprudence contains language which is decidedly less positive. This article takes an in-depth look at the situation concerning broad consent under the GDPR and-despite the understandable concern flowing from recent jurisprudence-offers a positive outlook. This positive outlook is argued from three perspectives, each of which is significant in defining the current, and ongoing, legitimacy and utility of broad consent under the GDPR: The principled, the legal technical, and the practical. © 2020 The Author(s).