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High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation
2020, Zou, Huajiao, Yang, Wenjuan, Schwär, Gertrud, Zhao, Renping, Alansary, Dalia, Yin, Deling, Schwarz, Eva C., Niemeyer, Barbara A., Qu, Bin
In CTLs: High glucose‐culture enhances thapsigargin‐induced SOCE but decreases target recognition‐induced Ca2+ influx. High glucose‐culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose‐cultured CTLs are prone to necrosis after execution of killing.