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Title: Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations
Authors: Lana, Gabriela MoreiraSorg, KatharinaWenzel, Gentiana IoanaHecker, DietmarHensel, RenéSchick, BernhardKruttwig, KlausArzt, Eduard
Publishers version: https://doi.org/10.1002/anbr.202100057
URI: https://oa.tib.eu/renate/handle/123456789/8215
http://dx.doi.org/10.34657/7253
Issue Date: 2021
Published in: Advanced NanoBiomed Research 1 (2021), Nr. 10
Publisher: Weinheim : Wiley-VCH
Abstract: Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations.
Keywords: silicone patches; microstructured adhesives; tympanic membrane perforations; distortion product otoacoustic emissions
Type: article; Text
Publishing status: publishedVersion
DDC: 570
610
License: CC BY 4.0 Unported
Link to license: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:Biowissenschaften
Medizin

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Lana, Gabriela Moreira, Katharina Sorg, Gentiana Ioana Wenzel, Dietmar Hecker, René Hensel, Bernhard Schick, Klaus Kruttwig and Eduard Arzt, 2021. Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations. 2021. Weinheim : Wiley-VCH
Lana, G. M., Sorg, K., Wenzel, G. I., Hecker, D., Hensel, R., Schick, B., Kruttwig, K. and Arzt, E. (2021) “Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations.” Weinheim : Wiley-VCH. doi: https://doi.org/10.1002/anbr.202100057.
Lana G M, Sorg K, Wenzel G I, Hecker D, Hensel R, Schick B, Kruttwig K, Arzt E. Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations. Vol. 1. Weinheim : Wiley-VCH; 2021.
Lana, G. M., Sorg, K., Wenzel, G. I., Hecker, D., Hensel, R., Schick, B., Kruttwig, K., & Arzt, E. (2021). Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations (Version publishedVersion, Vol. 1). Version publishedVersion, Vol. 1. Weinheim : Wiley-VCH. https://doi.org/https://doi.org/10.1002/anbr.202100057
Lana G M, Sorg K, Wenzel G I, Hecker D, Hensel R, Schick B, Kruttwig K, Arzt E. Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations. 2021;1(10). doi:https://doi.org/10.1002/anbr.202100057


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