Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

dc.bibliographicCitation.firstPage1307
dc.bibliographicCitation.journalTitleBeilstein journal of nanotechnologyeng
dc.bibliographicCitation.lastPage1317
dc.bibliographicCitation.volume8
dc.contributor.authorErdmann, Kati
dc.contributor.authorRingel, Jessica
dc.contributor.authorHampel, Silke
dc.contributor.authorWirth, Manfred P.
dc.contributor.authorFuessel, Susanne
dc.date.accessioned2022-12-21T13:10:35Z
dc.date.available2022-12-21T13:10:35Z
dc.date.issued2017-6-23
dc.description.abstractWe have previously shown that carbon nanofibers (CNFs) and carbon nanotubes (CNTs) can sensitize prostate cancer (PCa) cells to platinum-based chemotherapeutics. In order to further verify this concept and to avoid a bias, the present study investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycin C (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in combination with the carbon nanomaterials. The impact of the monotreatments and the combinatory treatments on cellular function was then systematically analyzed by using different experimental approaches (viability, short-term and long-term proliferation, cell death rate). DTX and MMC alone reduced the viability of PCa cells to 94% and 68%, respectively, whereas a combined treatment with CNFs led to less than 30% remaining viable cells. Up to 17- and 7-fold higher DTX and MMC concentrations were needed in order to evoke a similar inhibition of viability as mediated by the combinatory treatments. In contrast, the dose of platinum-based chemotherapeutics could only be reduced by up to 3-fold by combination with carbon nanomaterials. Furthermore, combinatory treatments with CNFs led mostly to an additive inhibition of short- and long-term proliferation compared to the individual treatments. Also, higher cell death rates were observed in combinatory treatments than in monotreatments, e.g., a combination of MMC and CNFs more than doubled the cell death rate mediated by apoptosis. Combinations with CNTs showed a similar, but less pronounced impact on cellular functions. In summary, carbon nanomaterials in combination with DTX and MMC evoked additive to partly synergistic anti-tumor effects. CNFs and CNTs possess the ability to sensitize cancer cells to a wide range of structurally diverse chemotherapeutics and thus represent an interesting option for the development of multimodal cancer therapies. Co-administration of chemotherapeutics with carbon nanomaterials could result in a reduction of the chemotherapeutic dosage and thus limit systemic side effects.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/10707
dc.identifier.urihttp://dx.doi.org/10.34657/9743
dc.language.isoeng
dc.publisherFrankfurt, M. : Beilstein-Institut zur Förderung der Chemischen Wissenschaften
dc.relation.doihttps://doi.org/10.3762/bjnano.8.132
dc.relation.essn2190-4286
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc620
dc.subject.ddc540
dc.subject.otherCarbon nanomaterialseng
dc.subject.otherChemosensitizationeng
dc.subject.otherDocetaxeleng
dc.subject.otherMitomycin Ceng
dc.subject.otherProstate cancer cellseng
dc.titleCarbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferationeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIFWD
wgl.subjectIngenieurwissenschaftenger
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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