Modular and Versatile Trans-Encoded Genetic Switches
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Date
2020
Volume
59
Issue
46
Journal
Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker : International edition
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Book Title
Publisher
Weinheim : Wiley-VCH
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Abstract
Current bacterial RNA switches suffer from lack of versatile inputs and are difficult to engineer. We present versatile and modular RNA switches that are trans-encoded and based on tRNA-mimicking structures (TMSs). These switches provide a high degree of freedom for reengineering and can thus be designed to accept a wide range of inputs, including RNA, small molecules, and proteins. This powerful approach enables control of the translation of protein expression from plasmid and genome DNA. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA
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Citation
Paul, A., Warszawik, E. M., Loznik, M., Boersma, A. J., & Herrmann, A. (2020). Modular and Versatile Trans-Encoded Genetic Switches (Weinheim : Wiley-VCH). Weinheim : Wiley-VCH. https://doi.org//10.1002/anie.202001372
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License
CC BY 4.0 Unported