The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
dc.bibliographicCitation.firstPage | 115 | eng |
dc.bibliographicCitation.journalTitle | Journal of Nanobiotechnology | eng |
dc.bibliographicCitation.volume | 17 | eng |
dc.contributor.author | Formicola, Beatrice | |
dc.contributor.author | Dal, Magro, Roberta | |
dc.contributor.author | Montefusco-Pereira, Carlos V. | |
dc.contributor.author | Lehr, Claus‑Michael | |
dc.contributor.author | Koch, Marcus | |
dc.contributor.author | Russo, Laura | |
dc.contributor.author | Grasso, Gianvito | |
dc.contributor.author | Deriu, Marco A. | |
dc.contributor.author | Danani, Andrea | |
dc.contributor.author | Bourdoulous, Sandrine | |
dc.contributor.author | Re, Francesca | |
dc.date.accessioned | 2020-01-14T06:56:41Z | |
dc.date.available | 2020-01-14T06:56:41Z | |
dc.date.issued | 2019 | |
dc.description.abstract | We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s). | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://doi.org/10.34657/116 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/4845 | |
dc.language.iso | eng | eng |
dc.publisher | London : BioMed Central | eng |
dc.relation.doi | https://doi.org/10.1186/s12951-019-0546-3 | |
dc.relation.essn | 1477-3155 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 570 | eng |
dc.subject.ddc | 610 | |
dc.subject.other | Blood-brain barrier | eng |
dc.subject.other | Brain | eng |
dc.subject.other | Chlorotoxin | eng |
dc.subject.other | Doxorubicin | eng |
dc.subject.other | Drug delivery | eng |
dc.subject.other | Glioblastoma | eng |
dc.subject.other | Liposomes | eng |
dc.subject.other | Nanoparticles | eng |
dc.title | The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | INM | eng |
wgl.subject | Ingenieurwissenschaften | eng |
wgl.type | Zeitschriftenartikel | eng |
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