The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

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dc.bibliographicCitation.firstPage115eng
dc.bibliographicCitation.journalTitleJournal of Nanobiotechnologyeng
dc.bibliographicCitation.volume17eng
dc.contributor.authorFormicola, Beatrice
dc.contributor.authorDal, Magro, Roberta
dc.contributor.authorMontefusco-Pereira, Carlos V.
dc.contributor.authorLehr, Claus‑Michael
dc.contributor.authorKoch, Marcus
dc.contributor.authorRusso, Laura
dc.contributor.authorGrasso, Gianvito
dc.contributor.authorDeriu, Marco A.
dc.contributor.authorDanani, Andrea
dc.contributor.authorBourdoulous, Sandrine
dc.contributor.authorRe, Francesca
dc.date.accessioned2020-01-14T06:56:41Z
dc.date.available2020-01-14T06:56:41Z
dc.date.issued2019
dc.description.abstractWe designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s).eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://doi.org/10.34657/116
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/4845
dc.language.isoengeng
dc.publisherLondon : BioMed Centraleng
dc.relation.doihttps://doi.org/10.1186/s12951-019-0546-3
dc.relation.essn1477-3155
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc570eng
dc.subject.ddc610
dc.subject.otherBlood-brain barriereng
dc.subject.otherBraineng
dc.subject.otherChlorotoxineng
dc.subject.otherDoxorubicineng
dc.subject.otherDrug deliveryeng
dc.subject.otherGlioblastomaeng
dc.subject.otherLiposomeseng
dc.subject.otherNanoparticleseng
dc.titleThe synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBBeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorINMeng
wgl.subjectIngenieurwissenschafteneng
wgl.typeZeitschriftenartikeleng
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