Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion

dc.bibliographicCitation.firstPage1903438
dc.bibliographicCitation.issue10
dc.bibliographicCitation.journalTitleAdvanced scienceeng
dc.bibliographicCitation.volume7
dc.contributor.authorBekeschus, Sander
dc.contributor.authorClemen, Ramona
dc.contributor.authorNießner, Felix
dc.contributor.authorSagwal, Sanjeev Kumar
dc.contributor.authorFreund, Eric
dc.contributor.authorSchmidt, Anke
dc.date.accessioned2022-08-22T06:03:04Z
dc.date.available2022-08-22T06:03:04Z
dc.date.issued2020
dc.description.abstractMedical technologies from physics are imperative in the diagnosis and therapy of many types of diseases. In 2013, a novel cold physical plasma treatment concept was accredited for clinical therapy. This gas plasma jet technology generates large amounts of different reactive oxygen and nitrogen species (ROS). Using a melanoma model, gas plasma technology is tested as a novel anticancer agent. Plasma technology derived ROS diminish tumor growth in vitro and in vivo. Varying the feed gas mixture modifies the composition of ROS. Conditions rich in atomic oxygen correlate with killing activity and elevate intratumoral immune-infiltrates of CD8+ cytotoxic T-cells and dendritic cells. T-cells from secondary lymphoid organs of these mice stimulated with B16 melanoma cells ex vivo show higher activation levels as well. This correlates with immunogenic cancer cell death and higher calreticulin and heat-shock protein 90 expressions induced by gas plasma treatment in melanoma cells. To test the immunogenicity of gas plasma treated melanoma cells, 50% of mice vaccinated with these cells are protected from tumor growth compared to 1/6 and 5/6 mice negative control (mitomycin C) and positive control (mitoxantrone), respectively. Gas plasma jet technology is concluded to provide immunoprotection against malignant melanoma both in vitro and in vivo.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/10090
dc.identifier.urihttp://dx.doi.org/10.34657/9128
dc.language.isoengeng
dc.publisherWeinheim : Wiley-VCH
dc.relation.doihttps://doi.org/10.1002/advs.201903438
dc.relation.essn2198-3844
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc500
dc.subject.ddc600
dc.subject.ddc624
dc.subject.otherB16F10eng
dc.subject.otherkINPeneng
dc.subject.otherplasma medicineeng
dc.subject.otherreactive nitrogen specieseng
dc.subject.otherreactive oxygen specieseng
dc.titleMedical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashioneng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorINP
wgl.subjectMedizin, Gesundheitger
wgl.subjectPhysikger
wgl.typeZeitschriftenartikelger
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