C-F bond activation under transition-metal-free conditions

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Date
2021
Volume
64
Issue
10
Journal
Series Titel
Book Title
Publisher
Beijing : Science China Press
Abstract

The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials, which have inspired the evolution of diverse C-F bond activation techniques. Although many advances have been made in functionalizations of activated C-F bonds utilizing transition metal complexes, there are fewer approaches available for nonactivated C-F bonds due to the difficulty in oxidative addition of transition metals to the inert C-F bonds. In this regard, using Lewis acid to abstract the fluoride and light/radical initiator to generate the radical intermediate have emerged as powerful tools for activating those inert C-F bonds. Meanwhile, these transition-metal-free processes are greener, economical, and for the pharmaceutical industry, without heavy metal residues. This review provides an overview of recent C-F bond activations and functionalizations under transition-metal-free conditions. The key mechanisms involved are demonstrated and discussed in detail. Finally, a brief discussion on the existing limitations of this field and our perspective are presented.

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Keywords
C-F activation, coupling, fluorinated compounds, transition-metal-free
Citation
Ai, H.-J., Ma, X., Song, Q., & Wu, X.-F. (2021). C-F bond activation under transition-metal-free conditions. 64(10). https://doi.org//10.1007/s11426-021-1040-2
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License
CC BY 4.0 Unported